HIV- and ART-ASSOCIATED CARDIOMETABOLIC RESEARCH TRAINING IN RWANDA

 描述(由申请者提供)：这一培训战略的总体目标是通过发展一支充满活力的学者团队，在卢旺达发展艾滋病毒和ART相关心脏代谢(CM)研究的科学领导力，以实施精心设计的背景相关研究，在科学会议上发表和展示结果，并建立网络，并为独立研究资金开发专门知识。区域可持续发展联盟(RASD卢旺达)和卢旺达大学(UR)医学与健康科学学院(UR-CMHS)建议与美国密苏里州圣路易斯市的华盛顿大学医学院(WUSTL)合作，实施一套长期、中期和短期的量身定制的授课和实践培训，平衡硕士(MS)学位和非学位面对面指导。我们将为博士后学者提供临床研究硕士培训，然后是为期3个月的辅导式职业发展奖学金，生物统计学硕士和生物化学实验室医学硕士。将提供内分泌学和新陈代谢的研究培训和先进的护理技术，以及用于底物动力学测量的稳定同位素示踪方法的技术培训，以及血管和心脏功能的超声心动图测量。在卢旺达职业生涯中期联合导师的协助下，WUSTL学院将利用卫生部现有的艾滋病毒数据集，在第一年向高级流行病学和生物统计学的15名职业中期调查人员提供为期4周的强化教学培训，并将其出版成出版物。在第二年，将进行为期4周的强化工作坊培训，以发展助学金写作技能，然后进行培训后的指导。有前途的年轻和职业生涯中期的科学家将受益于WUSTL高级教师和卢旺达联合导师(“被辅导者成为导师”)的定期、量身定制和灵活的指导，以加强UR-CMHS的研究文化，而卢旺达联合导师将从更有经验的学院获得广泛的技能，以培训初级科学家--未来的导师库。我们设想将有4个WUSTL学院每人指导4名年轻科学家，每年产生16个成功的导师，在5年内最多提供80个导师。学员独特的艾滋病毒研究项目将得到支持，以加速新的发现。此外，WUSTL全球卫生研究高级暑期教育计划和翻译实验室研究基础课程的暑期奖学金(8周)将每年接受2名实习生。回到卢旺达后，所有学员将融入充满活力的艾滋病毒研究基础设施，为严格的研究做出贡献，并最终使乌鲁木齐大学成为与艾滋病毒、营养、肥胖、糖尿病和其他相关共病相关的心血管和代谢研究的非洲科学领先者，提高吸引和管理赠款的独立科学能力，以及向全球社会通报艾滋病毒护理和实践的能力。

 DESCRIPTION (provided by applicant): The overall goal of this training strategy is to develop scientific leadership in HIV- and ART-associated cardiometabolic (CM) research in Rwanda through developing a dynamic team of scholars to implement well- designed contextually relevant studies, publish and present results at scientific meetings, and for networking, and develop expertise for independent research funding. Regional Alliance for Sustainable Development (RASD Rwanda) and University of Rwanda (UR) College of Medicine and Health Sciences (UR-CMHS) propose to collaborate with Washington University School of Medicine in St. Louis, MO, USA (WUSTL) to implement a mélange of long-, medium-, and short-term tailored didactic and hands-on training, balanced for Master's (MS) degree and non-degree face-to-face mentorships. We will provide MS in Clinical investigation training to postdoctoral scholars, followed by 3-months Mentored Career Development Fellowships, MS in Biostatistics, and MS in Biochemistry Laboratory Medicine. Research training in Endocrinology and Metabolism and advanced nursing techniques will be provided, plus technical training in stable isotope tracer methodologies for substrate kinetics measures, and echocardiographic measures of vascular and cardiac function. WUSTL Faculty assisted by previously trained mid-career Rwandan co-mentors will provide 4-weeks hands-on intensive didactic training to 15 mid-career investigators in Advanced Epidemiology & Biostatistics in Year 1, using existing Ministry of Health HIV datasets, resulting into publications. In Year 2, 4-week intensive workshop training to develop Grant Writing Skills will occur followed by post-training mentorships. Promising young and mid-career scientists will benefit from regular, custom-tailored and flexible mentoring from senior WUSTL Faculty and Rwandan co-mentors (the "mentored become mentors") to enhance the research culture at UR-CMHS, while Rwandan co-mentors will gain a breadth of skills from more experienced Faculty to train junior scientists- a pool of future mentors. We envision that 4 WUSTL Faculty will mentor 4 young scientists each, resulting in 16 successful mentorships annually, with up to 80 mentorships in 5 years. Trainees' unique HIV research projects will be supported to accelerate novel findings. Furthermore, WUSTL Summer Fellowships (8 weeks) in the Public Health Advanced Summer Education Program for Research in Global Health, and Bench Fundamentals for Translational Laboratory Research course will each accept 2 trainees/year. Upon return to Rwanda, all trainees will be integrated into the vibrant HIV research infrastructure to contribute to rigorous investigations, and to eventually enable UR to become an African scientific leader in cardiovascular and metabolic research associated with HIV, nutrition, obesity, diabetes and other related co- morbidities, with improved independent scientific capacity to attract and manage grants, and ability to inform global community on HIV care and practice.