WATER AND LIPID SUPPRESSION USING FREQUENCY-SELECTIVE RF PULSES FOR 1H MRSI

使用选频 RF 脉冲抑制 1H MRSI 的水和脂质

• 批准号: 7722934
• 负责人: MENG GU
• 金额: $ 1.12万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722934
• 关键词: Chemicals; Computer Retrieval of Information on Scientific Projects Database; Diagnosis; Frequencies; Funding; Grant; Institution; Lipids; Metabolic; Physiologic pulse; Pulse taking; Research; Research Personnel; Resources; Series; Signal Transduction; Source; Training; United States National Institutes of Health; Water; desire; in vivo; magnetic resonance spectroscopic imaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 1H magnetic resonance spectroscopic imaging has been increasingly used in diagnosis and treatment assessment in recent years. For in-vivo studies, water and lipid signals are large and, if not suppressed, greatly contaminate the desired metabolic information. Water suppression is typically achieved with a series of chemical shift selective (CHESS) pulses and dephasing gradient. Ogg et al, have previously demonstrated that optimizing the flip angles of the CHESS pulse train yields T1-and-B1 insensitive water suppression. Taking advantage of increased chemical shift dispersion at 3T, we extend this approach by using dualband frequency-selective preparatory RF pulses to suppress both water and lipid resonances. This approach yields robust water and lipid suppression with no loss of metabolic signals.

这个子项目是众多研究子项目之一