WATER AND LIPID SUPPRESSION USING FREQUENCY-SELECTIVE RF PULSES FOR 1H MRSI

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 近年来，~1H磁共振波谱成像在诊断和治疗评价中的应用越来越广泛。对于体内研究，水和脂肪信号很大，如果不加以抑制，就会极大地污染所需的代谢信息。水抑制通常通过一系列化学位移选择(CHESS)脉冲和退相梯度来实现。Ogg等人之前已经证明，优化国际象棋脉冲序列的翻转角可以产生T1和B1不敏感的水抑制。利用3T时化学位移色散增加的优势，我们通过使用双频频率选择性预备射频脉冲来抑制水和脂肪的共振，从而扩展了这种方法。这种方法产生了强大的水和脂肪抑制，而不会损失代谢信号。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 1H magnetic resonance spectroscopic imaging has been increasingly used in diagnosis and treatment assessment in recent years. For in-vivo studies, water and lipid signals are large and, if not suppressed, greatly contaminate the desired metabolic information. Water suppression is typically achieved with a series of chemical shift selective (CHESS) pulses and dephasing gradient. Ogg et al, have previously demonstrated that optimizing the flip angles of the CHESS pulse train yields T1-and-B1 insensitive water suppression. Taking advantage of increased chemical shift dispersion at 3T, we extend this approach by using dualband frequency-selective preparatory RF pulses to suppress both water and lipid resonances. This approach yields robust water and lipid suppression with no loss of metabolic signals.