WATER AND LIPID SUPPRESSION USING FREQUENCY-SELECTIVE RF PULSES FOR 1H MRSI

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 近年来，1H磁共振波谱成像越来越多地用于诊断和治疗评估。对于体内研究，水和脂质信号很大，如果不抑制，会极大地污染所需的代谢信息。水抑制通常通过一系列化学位移选择性（CHESS）脉冲和失相梯度来实现。Ogg等人先前已经证明，优化CHESS脉冲序列的翻转角产生T1和B1不敏感的水抑制。利用增加的化学位移分散在3 T，我们扩展了这种方法，通过使用双频带频率选择性的预备RF脉冲，以抑制水和脂质共振。这种方法产生了强大的水和脂质抑制，没有代谢信号的损失。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 1H magnetic resonance spectroscopic imaging has been increasingly used in diagnosis and treatment assessment in recent years. For in-vivo studies, water and lipid signals are large and, if not suppressed, greatly contaminate the desired metabolic information. Water suppression is typically achieved with a series of chemical shift selective (CHESS) pulses and dephasing gradient. Ogg et al, have previously demonstrated that optimizing the flip angles of the CHESS pulse train yields T1-and-B1 insensitive water suppression. Taking advantage of increased chemical shift dispersion at 3T, we extend this approach by using dualband frequency-selective preparatory RF pulses to suppress both water and lipid resonances. This approach yields robust water and lipid suppression with no loss of metabolic signals.