NEURAL CORRELATES OF COGNITIVE CONTROL IN MAJOR DEPRESSION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 背景：抑郁症患者经常出现反复出现的、无法控制的负面想法。这种反思性思维被认为在抑郁发作的发生和维持中起着重要作用。最近的研究表明，抑郁中的沉思可能部分是由于从工作记忆中删除无关的负面材料的困难。 目的：本研究旨在探讨认知控制困难的神经相关因素。 假设：鉴于额叶下回(IFG)在维持言语信息中起着不可或缺的作用，我们假设抑郁的个体在试图从工作记忆中消除负面信息的过程中，相对于非抑郁的对照组，IFG的激活会增加。 方法：参与者在接受扫描的同时完成一项修改后的斯特恩伯格任务。数据是在3T GE扫描仪上使用螺旋输入/螺旋输出采集序列采集的(格洛弗，2001)。所产生的数据使用AFNI进行处理，包括手动调整、归一化和平滑。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Depressed individuals frequently experience recurrent and uncontrollable negative thoughts. This ruminative thinking is postulated to play an important role in the onset and maintenance of depressive episodes. Recent work suggests that rumination in depression might be due in part to difficulties in removing irrelevant negative material from working memory. Objective: This study was designed to examine the neural correlates of this difficulty in cognitive control. Hypothesis: Given that the inferior frontal gyrus (IFG) plays an integral role in the maintenance of verbal information, we hypothesized that depressed individuals, relative to nondepressed controls, would exhibit increased IFG activation during attempted elimination of negative information from working memory. Methods: Participants completed a modified Sternberg task while being scanned. Data was acquired on a 3T GE scanner using a spiral in/spiral out acquisition sequence (Glover, 2001). Resulting data was processed using AFNI and included manual realignment, normalization and smoothing.