Superfund Chemical Impact on Development

描述（由申请人提供） 这一拟议的超级基金有害物质基础研究计划的主要主题是阐明人类和生态系统接触特定超级基金化学品的机制和毒性，这些化学品是根据其对发展影响的潜在重要性选定的。该计划的主要目标如下：1）阐明选定的超级基金化学品和化学混合物的发育毒性机制; 2）促进在选定的与人类和/或生态健康有关的无脊椎动物和脊椎动物模型中获得的机制信息的转移; 3）利用微阵列方法来评估我们模型中正常和扰动发育期间的基因表达，并增强这些模型的基因组数据库;（4）开发高度敏感和有效的发育毒性标记物，可纳入人类健康和生态评估;（5）阐明某些超级基金化学品的微生物和光解转化，这些转化增加了其环境归宿和对发展的影响; 6）使用地理信息系统（GIS）空间分析，在北卡罗来纳州开发和传播环境健康预防风险模型，该计划的主要目标是：（1）加强对儿童的教育;（2）将该计划的研究成果有效地提供给科学界、政府、商界和非专业界的重要成员;（3）加强生物医学和环境科学领域的跨学科研究以及本科生和研究生培训。

DESCRIPTION (provided by applicant) The major theme of this proposed Superfund Hazardous Substances Basic Research Program is the elucidation of mechanisms of exposure and toxicity in humans and ecosystems to particular Superfund chemicals selected based upon their potential significance with respect to developmental effects. The major goals of the Program are as follows: 1) to elucidate mechanisms of developmental toxicity of selected Superfund chemicals and chemical mixtures; 2) to facilitate the transfer of mechanistic information obtained across selected invertebrate and vertebrate models relevant to human and/or ecological health; 3) to utilize microarray approaches for assessing gene expression during normal and perturbed development in our models, and enhance the genomic database for these models; 4) to develop highly sensitive and efficient markers for developmental toxicities that can be incorporated into human health and ecological assessments; 5) to elucidate microbial and photolytic transformations of selected Superfund chemicals that augment their environmental fate and effects upon development; 6) to use Geographic Information Systems (GIS) spatial analysis to develop and disseminate preventive risk models for environmental health in North Carolina, with an emphasis on children; 7) to effectively deliver the Program's research results to critical members of the scientific, governmental, business and lay communities; and 8) to enhance interdisciplinary research, and graduate and post-graduate training, in the biomedical and environmental sciences.