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Superfund Chemical Impact on Development

超级基金对发展的化学影响

基本信息

批准号：
7638706
负责人：
Richard Di Giulio
金额：
$ 7.71万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-06-01 至 2010-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7638706
关键词：
Achievement Analytical Chemistry Animal Model Arts Basic Science Behavior assessment Biological Biological Assay Biological Markers Biomedical Research Businesses Caenorhabditis elegans Chemical Exposure Chemicals Chemistry Child Class Commit Communities Comparative Biology Cyprinodontidae Databases Development Developmental Biology Ecology Ecosystem Education Projects Educational workshop Elderly Engineering Environment Environmental Engineering technology Environmental Health Environmental Pollution Event Excision Exposure to Fertilization Fishes Flame Retardants Funding Fundulus Fundulus heteroclitus Gene Expression Genes Genomics Geographic Information Systems Goals Hazardous Substances Health Human Individual Infant Instruction Interdisciplinary Study Internet Invertebrates Joints Larva Life Medical center Modeling Molecular Biology Molecular Toxicology Mouse Cell Line Newsletter North Carolina Organism Participant Pathway interactions Pesticides Pharmacology and Toxicology Population Postdoctoral Fellow Predisposition Preventive Professional Practice Rattus Receptor Signaling Research Research Personnel Research Project Grants Research Support Research Training Risk Rodent Role Safety Schools Science Scientist Sea Urchins Services Site Social Sciences Solutions Staging Students System Technology Toxic effect Toxicology Training Translations Universities Vulnerable Populations Walking Zebrafish base biomedical scientist cost design developmental neurotoxicity embryo/fetus functional genomics insight interest member microbial nanomaterials novel outreach programs relating to nervous system remediation social superfund chemical symposium tool toxicant

项目摘要

The major theme of this proposed Superfund Hazardous Substances Basic Research Program is the elucidation of mechanisms of exposure and toxicity in humans and ecosystems to particular Superfund chemicals selected based upon their potential significance with respect to developmental effects. The major goals of the Program are as follows: 1) to elucidate mechanisms of developmental toxicity of selected Superfund chemicals and chemical mixtures; 2) to facilitate the transfer of mechanistic information obtained across selected invertebrate and vertebrate models relevant to human and/or ecological health; 3) to utilize microarray approaches for assessing gene expression during normal and perturbed development in our models, and enhance the genomic database for these models; 4) to develop highly sensitive and efficient markers for developmental toxicities that can be incorporated into human health and ecological assessments; 5) to elucidate microbial and photolytic transformations of selected Superfund chemicals that augment their environmental fate and effects upon development; 6) to use Geographic Information Systems (GIS) spatial analysis to develop and disseminate preventive risk models for environmental health in North Carolina, with an emphasis on children; 7) to effectively deliver the Program's research results to critical members of the scientific, governmental, business and lay communities; and 8) to enhance interdisciplinary research, and graduate and post-graduate training, in the biomedical and environmental sciences.

这一拟议的超级基金有害物质基础研究计划的主要主题是阐明人类和生态系统接触特定超级基金化学品的机制和毒性，这些化学品是根据其对发展影响的潜在重要性选定的。该计划的主要目标如下：1）阐明选定的超级基金化学品和化学混合物的发育毒性机制; 2）促进在选定的与人类和/或生态健康有关的无脊椎动物和脊椎动物模型中获得的机制信息的转移; 3）利用微阵列方法来评估我们模型中正常和扰动发育期间的基因表达，并增强这些模型的基因组数据库;（4）开发高度敏感和有效的发育毒性标记物，可纳入人类健康和生态评估;（5）阐明某些超级基金化学品的微生物和光解转化，这些转化增加了其环境归宿和对发展的影响; 6）使用地理信息系统（GIS）进行空间分析，以便在北卡罗来纳州制定和传播环境卫生预防风险模式，重点是儿童; 7）有效地提供该计划的研究成果，科学，政府，企业和非专业社区的关键成员;和8）加强跨学科研究，本科生和研究生培训，在生物医学和环境科学。