Superfund Chemical Impact on Development

描述(由申请人提供) 这项拟议的超级基金危险物质基础研究计划的主要主题是阐明特定超级基金化学品在人类和生态系统中的暴露和毒性机制，这些机制是根据特定超级基金化学品对发展影响的潜在意义而选择的。该计划的主要目标如下：1)阐明选定的超级基金化学品和化学混合物的发育毒性机制；2)促进与人类和/或生态健康有关的选定无脊椎动物和脊椎动物模型之间的机械信息传输；3)利用微阵列方法评估我们模型中正常和扰动发育期间的基因表达，并增强这些模型的基因组数据库；4)开发可纳入人类健康和生态评估的高度敏感和有效的发育毒性标记；5)阐明选定的超级基金化学品的微生物和光解转化，以增强其环境命运和对发育的影响；6)使用地理信息系统(GIS)空间分析来开发和传播北卡罗来纳州环境健康的预防性风险模型，重点是儿童；7)向科学、政府、商业和非专业社区的关键成员有效地提供该计划的研究成果；以及8)加强生物医学和环境科学方面的跨学科研究以及毕业生和研究生培训。

DESCRIPTION (provided by applicant) The major theme of this proposed Superfund Hazardous Substances Basic Research Program is the elucidation of mechanisms of exposure and toxicity in humans and ecosystems to particular Superfund chemicals selected based upon their potential significance with respect to developmental effects. The major goals of the Program are as follows: 1) to elucidate mechanisms of developmental toxicity of selected Superfund chemicals and chemical mixtures; 2) to facilitate the transfer of mechanistic information obtained across selected invertebrate and vertebrate models relevant to human and/or ecological health; 3) to utilize microarray approaches for assessing gene expression during normal and perturbed development in our models, and enhance the genomic database for these models; 4) to develop highly sensitive and efficient markers for developmental toxicities that can be incorporated into human health and ecological assessments; 5) to elucidate microbial and photolytic transformations of selected Superfund chemicals that augment their environmental fate and effects upon development; 6) to use Geographic Information Systems (GIS) spatial analysis to develop and disseminate preventive risk models for environmental health in North Carolina, with an emphasis on children; 7) to effectively deliver the Program's research results to critical members of the scientific, governmental, business and lay communities; and 8) to enhance interdisciplinary research, and graduate and post-graduate training, in the biomedical and environmental sciences.