RODENT IMAGING AND SPECTROSCOPY FACILITY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Two new state-of-the-art MR instruments will be installed in 2007. The objective is to provide imaging and spectroscopy at 7T and 9.4T for a wide range of users. The high fields for rodent studies have multiple advantages, including improved sensitivity, improved susceptibility - dependent measurements such as resolution of intra- from extra-myocellular fat, wider chemical shift dispersion, simpler J coupling patterns, and longer T1s that will benefit chemical exchange-dependent phenomena. The 7T will be a 16 cm RT bore instrument dedicated exclusively to 1H imaging; x nucleus will not be available. The 9.4T will be a 21 cm RT bore instrument devoted to research in ultra-high field imaging and spectroscopy including 13C, 31P, 23Na, etc., as well as optimal glycogen imaging.