FOURIER DOMAIN LOW COHERENCE INTERFEROMETRIC MICROSCOPY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们正在开发一个傅立叶域相位显微镜（FDPM）的反射模式研究细胞的电活动。该FDPM使用宽带光源连同一个共同的路径相位参考检测方案，以允许深度分辨的细胞位移测量在kHz带宽与埃尺度的灵敏度。SDPM的低噪声和高灵敏度将使测量细胞对单位脉冲刺激的反应成为可能。二维成像也可以通过优选地扫描样本光束来执行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are developing a Fourier domain phase microscope (FDPM) for reflection-mode studies of cell electromotility. The FDPM uses a broadband light source together with a common-path phase-referenced detection scheme to allow depth resolved measurements of cell displacements at kHz bandwidths with angstrom-scale sensitivity. The low-noise and high sensitivity of SDPM will make it possible to measure the cell response to a unit impulse stimulus. Two-dimensional imaging can also be performed by preferably scanning the sample beam.