MONTE CARLO MODELLING OF TRI-MODAL SPECTROSCOPY SPECTRA FOR DETECTION OF EARLY

用于早期检测的三模态光谱的蒙特卡罗建模

• 批准号: 7723212
• 负责人: MICHAEL Stephen FELD
• 金额: $ 0.05万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7723212
• 关键词: Biochemical; Biomedical Research; Code; Computer Retrieval of Information on Scientific Projects Database; Computers; Diffuse; Early Diagnosis; Fluorescence Spectroscopy; Funding; Grant; Institution; Intraepithelial Neoplasia; Lasers; Malignant Neoplasms; Modeling; Optics; Research; Research Personnel; Resources; Signal Transduction; Source; Specimen; Spectrum Analysis; Time; Tissues; United States National Institutes of Health; base; human subject; improved; in vivo; insight; light scattering; parallel processing; simulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The tri-modal spectroscopy (TMS) project of the Laser Biomedical Research Center (an NIH P41 Research Resource) employs the combination of light scattering, diffuse reflectance and intrinsic fluorescence spectroscopy to detect pre-cancer (epithelial dysplasia). Studies are being conducted on human subjects in vivo and on ex vivo tissue specimens. There is a pressing need to develop Monte Carlo simulations based on radiative transport to model the spectral signals. The results will provide information to improve TMS analysis and provide insight as to the way the morphological and biochemical tissue components manifest themselves in the optical signals. We have developed a Monte Carlo code and are using it in preliminary studies. However, because the numerical simulations are time consuming, a large parallel processing computer is required.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 激光生物医学研究中心（NIH P41研究资源）的三模态光谱（TMS）项目采用光散射，漫反射和固有荧光光谱的组合来检测癌前病变（上皮发育不良）。正在对人体受试者进行体内和离体组织标本研究。有一个迫切需要开发的Monte Carlo模拟的基础上辐射输运的光谱信号建模。结果将提供信息，以改善TMS分析，并提供洞察力的方式形态和生化组织成分表现自己的光学信号。我们已经开发了一个蒙特卡罗代码，并正在使用它的初步研究。然而，由于数值模拟是耗时的，需要大型并行处理计算机。