Spectroscopic imaging and diagnosis of neoplasia

肿瘤的光谱成像和诊断

• 批准号: 7119530
• 负责人: MICHAEL Stephen FELD
• 金额: $ 141.56万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-15 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7119530
• 关键词: bioimaging /biomedical imaging; biomarker; cervix neoplasms; clinical research; cooperative study; diagnosis design /evaluation; early diagnosis; fiber optics; histopathology; human subject; image enhancement; imaging /visualization /scanning; interdisciplinary collaboration; light scattering; mathematical model; neoplasm /cancer diagnosis; oral pharyngeal neoplasm; patient oriented research; preneoplastic state; prognosis; spectrometry; technology /technique development

DESCRIPTION (provided by applicant): This is a proposal to the National Institutes of Health to establish a Bioengineering Research Partnership to develop a spectroscopic imaging methodology for diagnosing pre-invasive neoplasia (dysplasia) and monitoring its progression. The proposed program is based on optical spectroscopic clinical instrumentation and associated diagnostic algorithms successfully developed at the MIT Spectroscopy Laboratory. The instrument to be developed will have two components, a system for wide-area imaging of neoplasia, based on light scattering spectroscopy i(LSS), and an optical fiber probe device for studying suspect regions thus revealed, based on tri-modal spectroscopy i(TMS). The goal of the program is to develop and perfect the new technology and assess its application to the diagnosis, characterization, and therapy of neoplastic progression in human patients in real time, The detection and monitoring of neoplastic lesions in the oral cavity and the cervix will be used as model systems for establishing the potential of the technology. In addition, basic studies to further improve the technology and its ability to characterize pre-invasive neoplasia will be conducted. Six projects will be undertaken, each led by an experienced investigator: (I) Prototype instruments and diagnostic algorithms for clinical studies will be developed, maintained and perfected. Clinical studies will be conducted on patients with suspected lesions in the (2) oral cavity and (3) uterine cervix to evaluate and perfect the technology for diagnosing and monitoring dysplasia and predicting the patient's response to chemopreventive and immunotherapeutic agents. Two basic projects aimed at enhancing the diagnostic accuracy of the clinical instrumentation will be undertaken, one (4) to explore the use of quasi-multiple scattered light to enhance the sensitivity and provide depth resolution to LSS imaging, and a second (5) to develop novel spectroscopic end-points based on well-characterized molecular and cellular events associated with the progression and regression of disease. (6) Pathology support activities will include analysis of oral and cervical tissues for molecular markers, and analysis of histologic sections of the same biopsy tissue by computer-assisted quantitative image analysis. An administrative core will coordinate the multidisciplinary activities of the program and insure information sharing and efficient communication. The partnership, composed of expert investigators at six institutions, will include experienced bioengineers with training in physics and mechanical/electrical engineering, pathologists experienced in cancer research, and hospital-based clinicians specializing in oral and cervical dysplasia.

描述(由申请人提供)：这是一项向国家卫生研究院提出的建议，旨在建立生物工程研究伙伴关系，以开发一种光谱成像方法来诊断侵袭前肿瘤(异型增生)并监测其进展。该计划基于麻省理工学院光谱学实验室成功开发的光学光谱学临床仪器和相关诊断算法。将要开发的仪器将有两个组成部分，一个是基于光散射光谱I(LSS)的肿瘤广域成像系统，另一个是基于三模光谱I(TMS)的用于研究可疑区域的光纤探头设备。该计划的目标是开发和完善这项新技术，并评估其在人类患者肿瘤进展的诊断、特征和治疗中的应用。口腔和宫颈肿瘤病变的检测和监测将被用作建立该技术潜力的模型系统。此外，还将进行基础研究，以进一步提高该技术及其表征侵袭前肿瘤的能力。将开展六个项目，每个项目由一名经验丰富的调查员领导：(I)将开发、维护和完善临床研究的原型仪器和诊断算法。将对(2)口腔和(3)宫颈可疑病变的患者进行临床研究，以评估和完善诊断和监测异型增生以及预测患者对化学预防和免疫治疗药物的反应的技术。将开展两个旨在提高临床仪器诊断准确性的基本项目，一个(4)探索使用准多重散射光来提高LSS成像的灵敏度和提供深度分辨率，以及(5)基于与疾病进展和消退相关的特征良好的分子和细胞事件开发新的光谱终点。(6)病理学支持活动将包括对口腔和宫颈组织进行分子标记分析，以及利用计算机辅助定量图像分析对同一活检组织的组织切片进行分析。行政核心将协调该方案的多学科活动，并确保信息共享和有效沟通。这一伙伴关系由来自六个机构的专家调查人员组成，其中将包括在物理和机械/电气工程方面接受过培训的经验丰富的生物工程师，在癌症研究方面经验丰富的病理学家，以及专门从事口腔和宫颈发育不良的医院临床医生。