COLLAGEN STRUCTURE UNDER TENSION W/ DEPTH AND AGE VARIATION IN BOVINE CARTILAGE

牛软骨中处于张力下的胶原蛋白结构随深度和年龄的变化

• 批准号: 7722450
• 负责人: Robert L Sah
• 金额: $ 0.1万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722450
• 关键词: Age; Biomechanics; Bos taurus; Bovine Cartilage; Cartilage; Cartilage Matrix; Cattle; Collagen; Collagen Fibril; Computer Retrieval of Information on Scientific Projects Database; Depth; Funding; Grant; Institution; Knee; Mechanics; Personal Satisfaction; Property; Research; Research Personnel; Resources; Source; Structure; Surface; Tissues; United States National Institutes of Health; Variant

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cartilage matrix components have been shown to vary in content and organization with age and vertical depth from the articular surface. This structural variation has been correlated to the anisotropic mechanical properties of cartilage. However, most of the structural studies of collagen have been performed on unstressed cartilage, and any changes that occur in the collagen structure during load have not been well-characterized. Determining the effect of tension on collagen fibril structure would help elucidate how cartilage tissue structure relates to its biomechanical function. The objective of this study is to elucidate changes in collagen structure in tension with varying depths and ages of bovine knee cartilage.

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