COMPARISON OF BOUNDARY-ELEMENT MODELS AND A FINITE-DIFFERENCE FORWARD MODEL

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 在我们之前的研究中，我们引入了使用皮质约束的功能磁共振成像加权脑磁图和脑电图源估计。在这种方法中，独立分析 fMRI 和 MEG/EEG 数据，并在 MEG/EEG 逆模型中采用显着 fMRI 活动的位置，以使解决方案偏向 fMRI 结果。该项目的目的是通过改进皮质约束的使用、创建在 MEG/EEG 源建模中利用 fMRI 信息的新方法以及将 fMRI/MEG/EEG 的分析集成到单个组合逆模型中来扩展该方法。组合建模方法的先决条件是建立血流动力学和电磁信号之间关系的模型，这些信号正在我们的人类功能磁共振成像、脑磁图、脑电图和光学联合研究以及我们的合作者进行的动物模型实验中进行研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In our previous studies we have introduced fMRI-weighted MEG and EEG source estimates employing cortical constraints. In this approach, fMRI and MEG/EEG data are analyzed independently and the locations of significant fMRI activity are employed in the MEG/EEG inverse model to bias the solution toward the fMRI result. The aim of this project is to extend this approach by refining the use of cortical constraints, by creating novel ways to utilize fMRI information in MEG/EEG source modeling, and by integrating the analysis of fMRI/MEG/EEG to a single combined inverse model. The prerequisite of the combined modeling approach is a model for the relationship between the hemodynamic and electromagnetic signals that are being studied in our combined human fMRI, MEG, EEG, and optical studies as well as experiments in animal models conducted by our collaborators.