COMPARISON OF BOUNDARY-ELEMENT MODELS AND A FINITE-DIFFERENCE FORWARD MODEL

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在我们以前的研究中，我们介绍了使用皮质约束的脑磁共振加权和脑电源估计。在这种方法中，fMRI和MEG/EEG数据是独立分析的，并且在MEG/EEG逆模型中使用显著的fMRI活动的位置来偏向fMRI结果。该项目的目的是通过改进皮质约束的使用，通过创建在脑磁图/脑电源建模中利用功能磁共振信息的新方法，以及通过将功能磁共振/脑磁图/脑电信号的分析整合到一个单一的组合逆模型来扩展该方法。联合建模方法的前提是建立血流动力学和电磁信号之间的关系模型，在我们的联合人体fMRI、MEG、EEG和光学研究中，以及我们的合作者进行的动物模型实验中，正在研究这些信号之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In our previous studies we have introduced fMRI-weighted MEG and EEG source estimates employing cortical constraints. In this approach, fMRI and MEG/EEG data are analyzed independently and the locations of significant fMRI activity are employed in the MEG/EEG inverse model to bias the solution toward the fMRI result. The aim of this project is to extend this approach by refining the use of cortical constraints, by creating novel ways to utilize fMRI information in MEG/EEG source modeling, and by integrating the analysis of fMRI/MEG/EEG to a single combined inverse model. The prerequisite of the combined modeling approach is a model for the relationship between the hemodynamic and electromagnetic signals that are being studied in our combined human fMRI, MEG, EEG, and optical studies as well as experiments in animal models conducted by our collaborators.