"BRAIN'S LINES": A METHOD OF NON-RIGID REGISTRATION OF TWO-DIMENSIONAL IMAGES

“脑线”：一种二维图像非刚性配准方法

• 批准号: 7724490
• 负责人: MARCO MARCHINI
• 金额: $ 0.26万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724490
• 关键词: Arteries; Atlases; Basal Ganglia; Brain; Clinical; Computer Retrieval of Information on Scientific Projects Database; Computer software; Couples; Funding; Grant; Image; Institution; Length; Localized; Magnetic Resonance Imaging; Meninges; Methods; Process; Radiation therapy; Research; Research Personnel; Resources; Sampling; Source; Structure; Surface; Text; United States National Institutes of Health; Veins; interest; neurosurgery; tumor; two-dimensional; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. "Brain's lines" will be a software for registration created to find corresponding points inside two images independent from their external coordinates. The project has clinical aims and can find applications in Neurosurgery, Neuroradiology, Radiotherapy. The software will enable to localize a normal or pathological structure, which is visible on the MRI of a subject, on an atlas, or to find the coordinates of structures, which are well delienated on an atlas, on the MRI of a subject, therefore in his ""real"" brain. It will be utilized even for MR images in which the brain is greatly deformed by pahologic processes (e.g. large tumors).The software ""Brain's lines"" will use MR images elaborated by segmentation and in which the componenets which are not of interest, as arteries, veins and meninges,have been erased from the image. The comparison is made betwen an MR section and the corresponding section of an atlas. Some landmarks must be identified on the couples of figures to match. This identification can be made manually by the clinician or they could be found automatically by the software. The localization of the corresponding points is found comparing corresponding lines which sample the two structures and calculating the ratio between th the length of the two lines or of their segments. These lines are as thin as possible to sample the surface very closely. These surfaces are partitioned in 3 compartments: cortex, white matter, ventricles and basal ganglia. Each compartment is elaborated in a different way. At the present state of the project there is a text in which I describe what I wish the software to make in order to obtain a graphic result.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 “Brain's lines”将是一个用于配准的软件，用于在两个图像中找到独立于其外部坐标的对应点。 该项目具有临床目的，可以在神经外科，神经放射学，放射治疗中找到应用。 该软件将使得能够定位在受试者的MRI上、在图谱上可见的正常或病理结构，或者能够找到在图谱上、在受试者的MRI上、因此在他的“真实的”大脑中的结构的坐标。它甚至将用于MR图像，其中大脑因病理过程（例如大肿瘤）而大大变形。软件““Brain's lines””将使用通过分割精心制作的MR图像，并且其中不感兴趣的成分（如动脉，静脉和脑膜）已从图像中删除。并与寰椎的相应切面进行了比较。必须在成对的图形上识别一些地标以进行匹配。这种识别可以由临床医生手动进行，或者可以由软件自动找到。 通过比较对两个结构进行采样的对应线，并计算两条线或其线段的长度之比，找到对应点的定位。这些线尽可能细，以便非常接近地对表面进行采样。这些表面分为3个区室：皮质、白色物质、脑室和基底神经节。每个隔间都以不同的方式精心制作。在该项目的目前状态有一个文本中，我描述了我希望软件，以获得图形结果。