MRI STUDIES OF THE BRAIN IN HEALTH AND ILLNESS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究将使用功能性磁共振脑成像（fMRI）来更好地了解神经精神疾病的神经生物学，如抽动秽语综合征，强迫症（OCD），注意缺陷多动障碍（ADHD），焦虑症，物质使用障碍，病理性赌博，情感疾病和破坏性行为障碍。临床经验表明，患有严重神经精神障碍的人最大的痛苦不是他们的主要诊断症状，而是他们的冲动控制，多动，注意力不集中和反应抑制的困难。这些问题跨越大多数诊断领域，是临床转诊的最常见原因之一。通过了解这些疾病中涉及的神经功能障碍，我们将能够更好地设计和评估新疗法的效果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will use functional MR brain imaging (fMRI) to understand better the neurobiology of neuropsychiatric disorders such as Tourette's syndrome, Obsessive-Compulsive Disorder (OCD), Attention Deficit Hyperactivity Disorder (ADHD), anxiety disorders, substance use disorders, pathological gambling, affective illness and disruptive behavior disorders. Clinical experience has shown that people with a serious neuropsychiatric disorder suffer most not from their primary diagnostic symptoms, but from their difficulties with impulse control, hyperactivity, inattention, and response inhibition. These problems cut across most diagnostic domains and are amongst the most frequent causes for clinical referral. By understanding the neural dysfunction involved in these disorders, we will be better able to design and assess the effects of new therapeutics.