FMRI OF IMPULSE CONTROL IN CHILDHOOD DISORDERS

儿童障碍中冲动控制的 FMRI

• 批准号: 7724503
• 负责人: BRADLEY S PETERSON
• 金额: $ 1.03万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724503
• 关键词: Adult; Attention; Attention deficit hyperactivity disorder; Brain; Brain imaging; Brain region; Child; Childhood; Clinical; Computer Retrieval of Information on Scientific Projects Database; Diagnostic; Disease; Event; Functional disorder; Funding; Gilles de la Tourette syndrome; Grant; Hyperactive behavior; Image; Institution; Modeling; Motor; Neurobiology; Obsessive-Compulsive Disorder; Pharmaceutical Preparations; Protocols documentation; Research; Research Personnel; Resources; Signal Transduction; Source; Symptoms; System; United States National Institutes of Health; base; behavior measurement; design; experience; inattention; neural circuit; neuropsychiatry; novel therapeutics; relating to nervous system; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term objective of this proposal is to use functional MR brain imaging (fMRI) to better understand the neural circuits that contribute to problems with impulse control in Tourette's syndrome, Obsessive-Compulsive Disorder (OCD), and Attention Deficit Hyperactivity Disorder (ADHD). Clinical experience has shown that children who have a serious neuropsychiatric disorder suffer most not from their primary diagnostic symptoms, but from their difficulties with impulse control, hyperactivity, inattention, and response inhibition. These associated problems cut across most diagnostic domains and are the most frequent cause for clinical referral. By understanding dysfunction in this circuitry we will be better able to design and assess the effects of new therapeutics for these problems. We aim to understand better the neurobiology of impulse control through the imaging of motor, attention, and inhibitory neural systems involved in the control of impulses in normal children and in children who have TS, OCD, or ADHD. Our specific aims are: 1) To use fMRI to study the neural basis of impulse control in 80 normal children and adults (7-50 years old), and to compare the brain activity in these normal subjects with the brain activity in 80 TS, 40 OCD, and 40 ADHD subjects. 2) To study the functional connectivity of brain regions that subserve impulse control. 3) To show that task-related changes in fMRI signal can predict important behavioral measures in our models of impulse control. 4) To determine the effects that stimulant medications have on the activity of impulse control circuits in 40 children who have ADHD. 5) To develop and apply to the study of our models of impulse control new "event-related" fMRI task activation protocols in 40 normal and 40 matched TS children and adults.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项建议的长期目标是使用功能性磁共振脑成像(FMRI)来更好地了解导致抽动症、强迫症(OCD)和注意缺陷多动障碍(ADHD)冲动控制问题的神经回路。临床经验表明，患有严重神经精神障碍的儿童最大的痛苦不是他们的主要诊断症状，而是他们在冲动控制、多动、注意力不集中和反应抑制方面的困难。这些相关问题跨越了大多数诊断领域，是临床转诊的最常见原因。通过了解这个回路中的功能障碍，我们将能够更好地设计和评估针对这些问题的新疗法的效果。我们的目标是通过对正常儿童和患有TS、OCD或ADHD的儿童参与冲动控制的运动、注意力和抑制神经系统的成像，更好地了解冲动控制的神经生物学。1)用fMRI研究80例正常儿童和成人(7-50岁)冲动控制的神经基础，并与80例TS、40例强迫症和40例ADHD患者的脑活动进行比较。2)研究大脑冲动控制区域的功能连通性。3)在我们的脉冲控制模型中，任务相关的fMRI信号变化可以预测重要的行为测量。4)探讨兴奋剂对40例ADHD患儿冲动控制回路活动的影响。5)在40名正常儿童和40名匹配的TS儿童和成人中，开发和应用新的“事件相关”fMRI任务激活方案，并将其应用于我们的脉冲控制模型的研究。