MRI STUDIES OF THE BRAIN IN HEALTH AND ILLNESS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究将使用功能磁共振脑成像(FMRI)来更好地了解神经精神疾病的神经生物学，如抽动症、强迫症(OCD)、注意缺陷多动障碍(ADHD)、焦虑症、物质使用障碍、病理性赌博、情感性疾病和破坏性行为障碍。临床经验表明，患有严重神经精神障碍的人最痛苦的不是他们的主要诊断症状，而是他们在冲动控制、多动、注意力不集中和反应抑制方面的困难。这些问题跨越了大多数诊断领域，是临床转诊的最常见原因之一。通过了解这些疾病所涉及的神经功能障碍，我们将能够更好地设计和评估新疗法的效果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will use functional MR brain imaging (fMRI) to understand better the neurobiology of neuropsychiatric disorders such as Tourette's syndrome, Obsessive-Compulsive Disorder (OCD), Attention Deficit Hyperactivity Disorder (ADHD), anxiety disorders, substance use disorders, pathological gambling, affective illness and disruptive behavior disorders. Clinical experience has shown that people with a serious neuropsychiatric disorder suffer most not from their primary diagnostic symptoms, but from their difficulties with impulse control, hyperactivity, inattention, and response inhibition. These problems cut across most diagnostic domains and are amongst the most frequent causes for clinical referral. By understanding the neural dysfunction involved in these disorders, we will be better able to design and assess the effects of new therapeutics.