FMRI OF IMPULSE CONTROL IN CHILDHOOD DISORDERS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 这项提案的长期目标是使用功能性磁共振脑成像（fMRI）来更好地了解导致抽动秽语综合征，强迫症（OCD）和注意力缺陷多动障碍（ADHD）冲动控制问题的神经回路。临床经验表明，患有严重神经精神障碍的儿童最大的痛苦不是他们的主要诊断症状，而是他们的冲动控制，多动，注意力不集中和反应抑制的困难。这些相关的问题跨越了大多数诊断领域，是临床转诊的最常见原因。通过了解这一电路的功能障碍，我们将能够更好地设计和评估这些问题的新疗法的效果。我们的目标是更好地了解冲动控制的神经生物学，通过成像的运动，注意力和抑制性神经系统参与控制冲动在正常儿童和儿童谁TS，强迫症，或多动症。我们的具体目标是：（1）应用功能磁共振成像（fMRI）研究80例正常儿童和成人（7-50岁）冲动控制的神经基础，并与80例TS、40例OCD和40例ADHD患者的脑活动进行比较。2)研究有助于冲动控制的大脑区域的功能连接。3)表明在我们的冲动控制模型中，与任务相关的fMRI信号变化可以预测重要的行为指标。4)确定刺激性药物对40名ADHD儿童冲动控制回路活动的影响。5)在40名正常和40名匹配的TS儿童和成人中开发并应用于我们的冲动控制模型的研究新的“事件相关”fMRI任务激活协议。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term objective of this proposal is to use functional MR brain imaging (fMRI) to better understand the neural circuits that contribute to problems with impulse control in Tourette's syndrome, Obsessive-Compulsive Disorder (OCD), and Attention Deficit Hyperactivity Disorder (ADHD). Clinical experience has shown that children who have a serious neuropsychiatric disorder suffer most not from their primary diagnostic symptoms, but from their difficulties with impulse control, hyperactivity, inattention, and response inhibition. These associated problems cut across most diagnostic domains and are the most frequent cause for clinical referral. By understanding dysfunction in this circuitry we will be better able to design and assess the effects of new therapeutics for these problems. We aim to understand better the neurobiology of impulse control through the imaging of motor, attention, and inhibitory neural systems involved in the control of impulses in normal children and in children who have TS, OCD, or ADHD. Our specific aims are: 1) To use fMRI to study the neural basis of impulse control in 80 normal children and adults (7-50 years old), and to compare the brain activity in these normal subjects with the brain activity in 80 TS, 40 OCD, and 40 ADHD subjects. 2) To study the functional connectivity of brain regions that subserve impulse control. 3) To show that task-related changes in fMRI signal can predict important behavioral measures in our models of impulse control. 4) To determine the effects that stimulant medications have on the activity of impulse control circuits in 40 children who have ADHD. 5) To develop and apply to the study of our models of impulse control new "event-related" fMRI task activation protocols in 40 normal and 40 matched TS children and adults.