FMRI OF IMPULSE CONTROL IN CHILDHOOD DISORDERS

儿童障碍中冲动控制的 FMRI

• 批准号: 7955770
• 负责人: BRADLEY S PETERSON
• 金额: $ 0.34万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955770
• 关键词: Adult; Attention; Attention deficit hyperactivity disorder; Brain; Brain imaging; Brain region; Child; Childhood; Clinical; Computer Retrieval of Information on Scientific Projects Database; Diagnostic; Disease; Event; Functional disorder; Funding; Gilles de la Tourette syndrome; Grant; Hyperactive behavior; Image; Institution; Modeling; Motor; Neurobiology; Obsessive-Compulsive Disorder; Pharmaceutical Preparations; Protocols documentation; Research; Research Personnel; Resources; Signal Transduction; Source; Symptoms; System; United States National Institutes of Health; base; behavior measurement; computational anatomy; design; experience; inattention; neural circuit; neuropsychiatry; novel therapeutics; relating to nervous system; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term objective of this proposal is to use functional MR brain imaging (fMRI) to better understand the neural circuits that contribute to problems with impulse control in Tourette's syndrome, Obsessive-Compulsive Disorder (OCD), and Attention Deficit Hyperactivity Disorder (ADHD). Clinical experience has shown that children who have a serious neuropsychiatric disorder suffer most not from their primary diagnostic symptoms, but from their difficulties with impulse control, hyperactivity, inattention, and response inhibition. These associated problems cut across most diagnostic domains and are the most frequent cause for clinical referral. By understanding dysfunction in this circuitry we will be better able to design and assess the effects of new therapeutics for these problems. We aim to understand better the neurobiology of impulse control through the imaging of motor, attention, and inhibitory neural systems involved in the control of impulses in normal children and in children who have TS, OCD, or ADHD. Our specific aims are: 1) To use fMRI to study the neural basis of impulse control in 80 normal children and adults (7-50 years old), and to compare the brain activity in these normal subjects with the brain activity in 80 TS, 40 OCD, and 40 ADHD subjects. 2) To study the functional connectivity of brain regions that subserve impulse control. 3) To show that task-related changes in fMRI signal can predict important behavioral measures in our models of impulse control. 4) To determine the effects that stimulant medications have on the activity of impulse control circuits in 40 children who have ADHD. 5) To develop and apply to the study of our models of impulse control new "event-related" fMRI task activation protocols in 40 normal and 40 matched TS children and adults.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该提案的长期目标是利用功能性磁共振脑成像 (fMRI) 更好地了解导致抽动秽语综合征、强迫症 (OCD) 和注意力缺陷多动障碍 (ADHD) 冲动控制问题的神经回路。临床经验表明，患有严重神经精神疾病的儿童遭受的最大痛苦不是其主要诊断症状，而是冲动控制困难、多动、注意力不集中和反应抑制。这些相关问题涉及大多数诊断领域，也是临床转诊的最常见原因。通过了解该电路的功能障碍，我们将能够更好地设计和评估针对这些问题的新疗法的效果。我们的目标是通过对正常儿童和患有 TS、OCD 或多动症儿童的冲动控制所涉及的运动、注意力和抑制神经系统的成像，更好地了解冲动控制的神经生物学。我们的具体目标是：1）利用功能磁共振成像研究80名正常儿童和成人（7-50岁）冲动控制的神经基础，并将这些正常受试者的大脑活动与80名TS、40名强迫症和40名ADHD受试者的大脑活动进行比较。 2）研究有助于冲动控制的大脑区域的功能连接。 3）表明功能磁共振成像信号中与任务相关的变化可以预测我们的冲动控制模型中的重要行为测量。 4) 确定兴奋剂药物对 40 名 ADHD 儿童的冲动控制回路活动的影响。 5) 在 40 名正常和 40 名匹配的 TS 儿童和成人中开发新的“事件相关”fMRI 任务激活方案并将其应用于我们的冲动控制模型的研究。