IN VIVO BRAIN MECHANISMS ACROSS THE BIPOLAR SPECTRUM

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这位候选人是德克萨斯大学圣安东尼奥健康科学中心(UTHSCSA)的精神病学和放射学副教授和克勒斯捐赠的精神病学教授，他还在那里担任情绪和焦虑障碍科主任。他也是南得克萨斯州退伍军人医疗保健系统退伍军人精神病学研究的负责人。苏亚雷斯博士领导了他的独立研究实验室，该实验室专注于情绪障碍的脑成像研究，并在不同层面指导了几名实习生和年轻的研究人员。在职业生涯中期，他建议继续发展他的研究和学术活动，并投入大量时间指导年轻研究人员以患者为导向的精神病学研究，特别是在情绪障碍和脑成像领域。这些活动与UTHSCSA综合临床研究中心(GCRC)的计划密切相关。这里提出的职业发展计划将利用NCRR K24奖的职业生涯中期机制来促进苏亚雷斯博士的学术生涯，并让他有大量的时间继续致力于研究活动和指导以患者为导向的研究。它将集中于双相情感障碍病因中涉及的神经生物学机制的研究。K24的应用涉及一个发展(试点)研究项目，将对30名I型双相和30名II型双相患者进行磁共振成像(MR！)研究。和光谱学(MRS)，以开始检查涉及双极光谱的神经生物学机制。我们的初步研究将为R01的应用提供初步数据，这将进一步测试这一假设，即双相情感障碍患者额缘脑区的脑异常沿连续统分布，这反映了这些患者的临床症状谱。这些活动可能会对更好地了解双相情感障碍的病理生理学做出实质性贡献。拟议的K24计划将使候选人有必要的时间继续发展他的独立研究实验室，并专注于指导新一代年轻研究人员在精神病学领域以患者为导向的研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The candidate is an Associate Professor of Psychiatry and Radiology and Krus Endowed Chair in Psychiatry at the University of Texas Health Science Center in San Antonio (UTHSCSA), where he also holds the position of Chief, Division of Mood and Anxiety Disorders. He also is Chief, VA Psychiatry Research, South Texas Veterans Health Care System. Dr. Soares has led his independent research lab, which focuses on brain imaging studies on mood disorders, and has mentored several trainees and young investigators at various levels. At the mid-career stage, he is proposing to continue to develop his research and academic activities, and dedicate a substantial amount of time to mentoring young investigators on patient-oriented research in Psychiatry, in particular in the fields of mood disorders and brain imaging. These activities are very inter-linked to the program at the General Clinical Research Center (GCRC) at UTHSCSA. The career development plan proposed here will utilize the mid-career mechanism of the NCRR K24 award to foster Dr. Soares' academic career and allow substantial time for him to continue to dedicate to research activities and mentoring on patient-oriented research. It will focus on studies of the neurobiological mechanisms implicated in causation of bipolar disorder. The K24 application involves a developmental (pilot) research project where 30 bipolar type I and 30 bipolar type II patients will be studied with magnetic resonance imaging (MR!) and spectroscopy (MRS), to begin to examine neurobiological mechanisms implicated across,the bipolar spectrum. Our pilot study will elicit preliminary data towards an R01 application that will further test the hypothesis that brain abnormalities in fronto-limbic brain regions in bipolar spectrum patients are distributed along a continuum, which reflects the spectrum of clinical symptoms seen in these patients. These activities are likely to result in substantial contributions to a better understanding of the pathophysiology of bipolar spectrum disorders. The proposed K24 plan will give the candidate the needed time to continue to develop his independent research lab and to focus on mentoring the new generation of young investigators on patient-oriented research in the field of Psychiatry.