structural biology

结构生物学

• 批准号: 7339472
• 负责人: Alfonso Mondragon
• 金额: $ 16.9万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7339472
• 关键词: Area; Arts; Biochemistry; Biological; Biological Sciences; Biophysics; Cancer Center; Cellular biology; Charge; Chemicals; Chemistry; Chicago; Communities; Computational Biology; Crystallization; Crystallography; Data Collection; Development; Drug Design; Equipment; Funding; Generations; Growth; Imagery; Individual; Laboratories; Malignant Neoplasms; Modeling; Molecular; Molecular Biology; Molecular Structure; Nature; Pharmacology; Phase; Photons; Physics; Proteins; Reader; Research; Research Personnel; Resources; Robot; Roentgen Rays; Science; Source; Structural Biologist; Structure; Techniques; Time; Universities; Work; X ray diffraction analysis; X-Ray Diffraction; base; beamline; cooking; cost; design; drug discovery; falls; instrument; instrumentation; interest; light scattering; macromolecule; medical schools; member; programs; protein structure; research study; structural biology; synchrotron radiation

The Structural Biology Facility provides: a) resources required for crystallographic structure determination, refinement and analysis, b) molecular graphics and computational support for structural biology, c) molecular graphics and computational support for structure-based drug discovery and d) highly specialized resources for macromolecular characterization related to structural biology. The Facility is essential for the research programs of investigators of the Cancer Center who are studying the relationship between macromolecular structure and function or who are using macromolecular structure as the starting point for structure-based drug design. It is a unique resource at Northwestern University that capitalizes on the extensive expertise of a large group of users and the unique access to the synchrotron radiation X-ray source at Argonne National Laboratories. It also serves to nucleate the development of a local community with expertise in structural and computational biology. Such expertise will increasingly be called upon as the structures of more cancerrelated proteins become available. The Structural Biology Facility is, as are its investigators, located on both campuses of Northwestern University, based in the Department of Biochemistry, Molecular Biology and Cell Biology on the Evanston campus, in the Department of Molecular Pharmacology and Biological Chemistry at the Medical School campus, and also at the LS-CAT sector of Advanced Photon Source. Dr. Alfonso Mondragon, a structural biologist at the Evanston Campus, directs the Facility. The Facility consists of four major components: 1) an outstation at the APS that is devoted to state-of-the-art macromolecular crystallography, 2) X-ray diffraction facilities at the Chicago and Evanston campuses to support preliminary and more routine crystallographic experiments, 3) computational facilities at both campuses to support structural determination calculations, both NMR and crystallographic, computational drug-design, and modeling efforts, including advanced graphical visualization and manipulation of models, and 4) a relatively new component which provides automated facilities for setting up and visualizing crystallization experiments and for characterization of macromolecules for structural studies. The distributed nature of the facility reflects the means by which the data collection, computational, molecular visualization, and other scientific resources are networked, and thus integrated, for the structural biology research community at Northwestern.

结构生物学设施提供：a）晶体结构测定所需的资源， 精细化和分析，B）结构生物学的分子图形和计算支持，c）分子 为基于结构的药物发现提供图形和计算支持，以及d）高度专业化的资源 用于与结构生物学相关的大分子表征。该设施对研究至关重要 癌症中心的研究人员正在研究大分子之间的关系， 结构和功能，或以大分子结构为出发点， 药物设计这是西北大学的一个独特资源，它利用了 一个庞大的用户群和对阿贡国家实验室同步辐射X射线源的独特访问 Laboratories.它还有助于发展一个具有结构和技术专长的当地社区， 计算生物学随着越来越多的癌症相关组织的结构， 蛋白质变得可用。 结构生物学设施，因为是它的调查人员，位于西北大学的两个校区 大学，总部设在生物化学系，分子生物学和细胞生物学的埃文斯顿 医学院分子药理学和生物化学系 校园，也在LS-CAT先进光子源部门。阿方索蒙德拉贡博士，一位 埃文斯顿校区的生物学家，负责该设施。该基金由四个主要部分组成： APS的分站致力于最先进的大分子晶体学，2）X射线衍射 在芝加哥和埃文斯顿校区的设施，以支持初步和更常规的晶体 实验，3）两个校区的计算设施，以支持结构测定计算， 核磁共振和晶体学、计算药物设计和建模工作，包括先进的 模型的图形可视化和操作，以及4）一个相对新的组件， 自动化设备，用于设置和可视化结晶实验以及表征 用于结构研究的大分子。设施的分布式性质反映了 数据收集、计算、分子可视化和其他科学资源是联网的， 因此，整合，为结构生物学研究社区在西北。