Adenosinergic Mechanisms of Intrauterine Growth Retardation
Adenosinergic Mechanisms of Intrauterine Growth Retardation
批准号:
7738656
负责人:
SCOTT A. RIVKEES
金额:
$41.38万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-09-30 至 2011-08-31
关键词:
AcuteAdenosineAdenosine A1 ReceptorAdultAdverse effectsAffectAir PollutionAmericanBody CompositionBody fatCaffeineCardiacCardiovascular DiseasesCoffeeCongenital Heart DefectsConsumptionDevelopmentDiabetes MellitusDiseaseDoseElementsEmbryoEmbryonic DevelopmentEnvironmental Risk FactorEpigenetic ProcessEtiologyFetal DevelopmentFetal Growth RetardationFoundationsGene ExpressionGenomicsGoalsGrowthHeartHypoxiaInfantLong-Term EffectsMediatingMetabolic syndromeModificationMusNutrientObesityOrganogenesisOxygenPatternPlayPredispositionPregnancyPregnant WomenPublic HealthRisk FactorsRoleSignal TransductionSiteSmokingSpontaneous abortionTestingTissuesTransgenic MiceUnited StatesVentricularWomanbasecardiogenesiscostfetal programminghealth economicshigh riskhypoxia inducible factor 1in uteroinsightlifetime risknovel strategiesoffspringprenatalpreventprotective effectprotein expressionstressor
中文摘要
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英文摘要
Compelling evidence suggests that alteration of normal prenatal development influences one’s lifetime risks for obesity and cardiovascular disorders, which are components of the metabolic syndrome. Reflecting the public health importance of elucidating risk factors for obesity and cardiovascular disease, the metabolic syndrome affects nearly 50 million Americans. Thus, efforts aimed at elucidating the risk factors for adult disease, including those that contribute to a small element of causation, are of major public health and economic importance. The goals of this proposal are to identify the mechanisms by which adenosine acts to protect the embryo in utero and how altered embryonic adenosine action leads to long-term adverse effects in adulthood.
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