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Compelling evidence suggests that alteration of normal prenatal development influences one’s lifetime risks for obesity and cardiovascular disorders, which are components of the metabolic syndrome. Reflecting the public health importance of elucidating risk factors for obesity and cardiovascular disease, the metabolic syndrome affects nearly 50 million Americans. Thus, efforts aimed at elucidating the risk factors for adult disease, including those that contribute to a small element of causation, are of major public health and economic importance. The goals of this proposal are to identify the mechanisms by which adenosine acts to protect the embryo in utero and how altered embryonic adenosine action leads to long-term adverse effects in adulthood.
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Prevention of White Matter Injury in Premature Infants
  • 批准号:
    10028283
  • 项目类别:
  • 资助金额:
    $99.33万
  • 财政年份:
    2020
  • 负责人:
    SCOTT A. RIVKEES
  • 依托单位:
Prevention of White Matter Injury in Premature Infants
  • 批准号:
    10164837
  • 项目类别:
  • 资助金额:
    $70.06万
  • 财政年份:
    2020
  • 负责人:
    SCOTT A. RIVKEES
  • 依托单位:
Development of a Novel Therapeutic for Hyperthyroidism
  • 批准号:
    9908579
  • 项目类别:
  • 资助金额:
    $22.5万
  • 财政年份:
    2019
  • 负责人:
    SCOTT A. RIVKEES
  • 依托单位:
Discovery of Oligodendrocyte Stimulators
  • 批准号:
    9046803
  • 项目类别:
  • 资助金额:
    $21.78万
  • 财政年份:
    2015
  • 负责人:
    SCOTT A. RIVKEES
  • 依托单位:
国内基金
海外基金
基于ADK/Adenosine调控DNA甲基化探讨“利湿化瘀通络”法对2型糖尿病肾病足细胞裂孔膜损伤的干预机制研究
  • 批准号:
    82074359
  • 项目类别:
    面上项目
  • 资助金额:
    55.0万元
  • 批准年份:
    2020
  • 负责人:
    安晓飞
  • 依托单位:
细胞外腺苷(Adenosine)作为干细胞旁分泌因子的生物学鉴定和功能分析
Adenosine诱导A1/A2AR稳态失衡启动慢性低灌注白质炎性损伤及其机制