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Compelling evidence suggests that alteration of normal prenatal development influences one’s lifetime risks for obesity and cardiovascular disorders, which are components of the metabolic syndrome. Reflecting the public health importance of elucidating risk factors for obesity and cardiovascular disease, the metabolic syndrome affects nearly 50 million Americans. Thus, efforts aimed at elucidating the risk factors for adult disease, including those that contribute to a small element of causation, are of major public health and economic importance. The goals of this proposal are to identify the mechanisms by which adenosine acts to protect the embryo in utero and how altered embryonic adenosine action leads to long-term adverse effects in adulthood.
期刊论文(9)
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会议论文
DOI: 10.1186/1471-213x-11-37
发表时间: 2011-06-13
期刊: BMC developmental biology
影响因子: --
作者: [Poulsen RR, McClaskey CM, Rivkees SA, Wendler CC]
通讯作者: Wendler CC
Identification of the heart as the critical site of adenosine mediated embryo protection.
确定心脏是腺苷介导的胚胎保护的关键部位。
DOI: 10.1186/1471-213x-10-57
发表时间: 2010
期刊: BMC developmental biology
影响因子: --
作者: [Wendler,ChristopherC, Poulsen,RyanR, Ghatpande,Satish, Greene,RobertW, Rivkees,ScottA]
通讯作者: Rivkees,ScottA
DOI: 10.1161/atvbaha.111.226811
发表时间: 2012-04
期刊: Arteriosclerosis, thrombosis, and vascular biology
影响因子: --
作者: [Rivkees SA, Wendler CC]
通讯作者: Wendler CC
DOI: 10.1371/journal.pone.0087547
发表时间: 2014
期刊: PloS one
影响因子: 3.7
作者: [Buscariollo DL, Fang X, Greenwood V, Xue H, Rivkees SA, Wendler CC]
通讯作者: Wendler CC
Prevention of White Matter Injury in Premature Infants
  • 批准号:
    10028283
  • 项目类别:
  • 资助金额:
    $99.33万
  • 财政年份:
    2020
  • 负责人:
    SCOTT A. RIVKEES
  • 依托单位:
Prevention of White Matter Injury in Premature Infants
  • 批准号:
    10164837
  • 项目类别:
  • 资助金额:
    $70.06万
  • 财政年份:
    2020
  • 负责人:
    SCOTT A. RIVKEES
  • 依托单位:
Development of a Novel Therapeutic for Hyperthyroidism
  • 批准号:
    9908579
  • 项目类别:
  • 资助金额:
    $22.5万
  • 财政年份:
    2019
  • 负责人:
    SCOTT A. RIVKEES
  • 依托单位:
Discovery of Oligodendrocyte Stimulators
  • 批准号:
    9046803
  • 项目类别:
  • 资助金额:
    $21.78万
  • 财政年份:
    2015
  • 负责人:
    SCOTT A. RIVKEES
  • 依托单位:
国内基金
海外基金
基于ADK/Adenosine调控DNA甲基化探讨“利湿化瘀通络”法对2型糖尿病肾病足细胞裂孔膜损伤的干预机制研究
  • 批准号:
    82074359
  • 项目类别:
    面上项目
  • 资助金额:
    55.0万元
  • 批准年份:
    2020
  • 负责人:
    安晓飞
  • 依托单位:
细胞外腺苷(Adenosine)作为干细胞旁分泌因子的生物学鉴定和功能分析
Adenosine诱导A1/A2AR稳态失衡启动慢性低灌注白质炎性损伤及其机制