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Adenosinergic Mechanisms of Intrauterine Growth Retardation

子宫内生长迟缓的腺苷能机制

基本信息

批准号：
7938832
负责人：
SCOTT A. RIVKEES
金额：
$ 41.02万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7938832
关键词：
Acute Adenosine Adenosine A1 Receptor Adult Adverse effects Affect Air Pollution American Body Composition Body fat Caffeine Cardiac Cardiovascular Diseases Coffee Congenital Heart Defects Consumption Development Diabetes Mellitus Disease Dose Elements Embryo Embryonic Development Environmental Risk Factor Epigenetic Process Etiology Fetal Development Fetal Growth Retardation Foundations Gene Expression Genomics Goals Growth Heart Hypoxia Infant Long-Term Effects Mediating Metabolic Metabolic syndrome Modification Mus Nutrient Obesity Organogenesis Oxygen Pattern Physiology Play Population Predisposition Pregnancy Pregnant Women Proteins Public Health Risk Factors Role Signal Transduction Site Smoking Testing Tissues Transgenic Mice Ventricular Woman adverse outcome base cardiogenesis cost fetal programming health economics high risk hypoxia inducible factor 1 in utero insight lifetime risk novel strategies offspring prenatal prevent protective effect stressor young adult

项目摘要

Compelling evidence suggests that alteration of normal prenatal development influences one’s lifetime risks for obesity and cardiovascular disorders, which are components of the metabolic syndrome. Reflecting the public health importance of elucidating risk factors for obesity and cardiovascular disease, the metabolic syndrome affects nearly 50 million Americans. Thus, efforts aimed at elucidating the risk factors for adult disease, including those that contribute to a small element of causation, are of major public health and economic importance. The goals of this proposal are to identify the mechanisms by which adenosine acts to protect the embryo in utero and how altered embryonic adenosine action leads to long-term adverse effects in adulthood.

令人信服的证据表明，正常产前发育的改变会影响一个人一生中肥胖和心血管疾病的风险，这是代谢综合征的组成部分。代谢综合征影响了近5000万美国人，这反映了阐明肥胖和心血管疾病的危险因素对公共卫生的重要性。因此，旨在阐明成人疾病风险因素的努力，包括那些促成一小部分因果关系的因素，具有重大的公共卫生和经济意义。本研究的目的是确定腺苷在子宫内保护胚胎的机制，以及胚胎腺苷作用的改变如何导致成年期的长期不良影响。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The Sphingosine-1-phospate receptor 1 mediates S1P action during cardiac development.

DOI：
10.1186/1471-213x-11-37
发表时间：
2011-06-13
期刊：
BMC developmental biology
影响因子：
0
作者：
Poulsen RR;McClaskey CM;Rivkees SA;Wendler CC
通讯作者：
Wendler CC

Identification of the heart as the critical site of adenosine mediated embryo protection.

确定心脏是腺苷介导的胚胎保护的关键部位。

DOI：
10.1186/1471-213x-10-57
发表时间：
2010
期刊：
BMC developmental biology
影响因子：
0
作者：
Wendler,ChristopherC;Poulsen,RyanR;Ghatpande,Satish;Greene,RobertW;Rivkees,ScottA
通讯作者：
Rivkees,ScottA

Embryonic caffeine exposure acts via A1 adenosine receptors to alter adult cardiac function and DNA methylation in mice.