Superconducting Gradient Coil for Targeted Therapy by Micro-particle Navigation

用于微粒导航靶向治疗的超导梯度线圈

• 批准号: 8000932
• 负责人: Shahin Pourrahimi
• 金额: $ 56.5万
• 依托单位: SUPERCONDUCTING SYSTEMS, INC
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-26 至 2012-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8000932
• 关键词: Address; Animals; Arteries; Arts; Blood; Budgets; Cancer Intervention; Cancerous; Consultations; Development; Drug Delivery Systems; Engineering; FDA approved; Human; Image; Laboratories; Laboratory Animals; Lead; Life; Magnetic Resonance Imaging; Magnetism; Medical; Methods; Movement; Navigation System; Performance; Pharmaceutical Preparations; Phase; Physiologic pulse; Safety; Small Business Innovation Research Grant; Solutions; Stream; System; Technology; Time; Tissues; United States National Institutes of Health; Work; base; clinically relevant; design; human subject; in vivo; innovation; magnetic field; minimally invasive; nanorobotics; new technology; operation; particle; programs; public health relevance; response; superconductivity

DESCRIPTION (provided by applicant): Our proposal introduces novel technologies that facilitate designing and manufacturing three- axis magnetic gradient coils for in vivo navigation of drug carrying particles in human arteries that are traceable by an MRI scanner. Developing a practical in vivo particle navigator can lead to very effective minimally invasive medical treatments, perhaps most importantly drug delivery to cancerous tissue. The NanoRobotics Laboratory Ecole Polytechnique Montreal (NLEPM) has demonstrated principles of image-based particle navigation by use of MRI hardware. Recent work by NLEPM, who is a collaborator in our proposed work, has indicated a need for magnetic field gradient strength of hundreds of mT/m to navigate micro-particle that can be used as carries of drugs. Our proposed Phase II work intends to design and build fully functional superconducting gradient coils that can achieve 500 mT/m, which can be used in Navigation of micro-particles in midsize animals. PUBLIC HEALTH RELEVANCE: Our proposal introduces novel technologies that facilitate designing and manufacturing three- axis magnetic gradient coils for in vivo navigation of drug carrying particles in human arteries that are traceable by an MRI scanner. Developing a practical in vivo particle navigator can lead to very effective minimally invasive medical treatments, perhaps most importantly drug delivery to cancerous tissue. In the Phase II program we will build and commission a fully functional superconducting gradient coil with gradient strength of 500 mT/m to demonstrate navigation of micro-particles in midsize animals.

描述（由申请人提供）：我们的提案介绍了新技术，这些技术有助于设计和制造三轴磁梯度线圈，用于人体动脉中载药颗粒的体内导航，这些颗粒可通过 MRI 扫描仪进行追踪。开发实用的体内粒子导航器可以实现非常有效的微创医疗，也许最重要的是向癌组织输送药物。蒙特利尔综合理工学院纳米机器人实验室 (NLEPM) 展示了使用 MRI 硬件进行基于图像的粒子导航的原理。 NLEPM（我们提议的工作的合作者）最近的工作表明，需要数百 mT/m 的磁场梯度强度来导航可用作药物载体的微粒。我们提出的第二阶段工作旨在设计和构建功能齐全的超导梯度线圈，可实现 500 mT/m，可用于中型动物的微粒导航。 公共健康相关性：我们的提案引入了新技术，有助于设计和制造三轴磁梯度线圈，用于体内导航人体动脉中携带药物的颗粒，这些颗粒可通过 MRI 扫描仪进行追踪。开发实用的体内粒子导航器可以实现非常有效的微创医疗，也许最重要的是向癌组织输送药物。在第二阶段项目中，我们将建造并调试一个梯度强度为 500 mT/m 的功能齐全的超导梯度线圈，以演示中型动物体内微粒的导航。