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Superconducting Gradient Coil for Targeted Therapy by Micro-particle Navigation

用于微粒导航靶向治疗的超导梯度线圈

基本信息

批准号：
7612591
负责人：
Shahin Pourrahimi
金额：
$ 14.99万
依托单位：
SUPERCONDUCTING SYSTEMS, INC
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-26 至 2009-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7612591
关键词：
Address Arteries Arts Benchmarking Blood Caliber Cancer Intervention Cancerous Characteristics Clinical Development Drug Delivery Systems Engineering Environment Equipment Heat Losses Heating Helium Human Image Invasive Laboratories Lead Life Liquid substance MRI Scans Magnetic Resonance Imaging Magnetism Medical Methods Modeling Movement Operative Surgical Procedures Performance Personal Satisfaction Pharmaceutical Preparations Phase Physiologic pulse Public Health Pulse taking Rate Running Safety Small Business Funding Mechanisms Small Business Innovation Research Grant Solutions Staging Stream Structure System Technology Temperature Testing Time Tissues United States Food and Drug Administration United States National Institutes of Health Work base clinically relevant cryogenics design in vivo innovation magnetic field nanorobotics new technology particle programs response size superconductivity

项目摘要

DESCRIPTION (provided by applicant): Our proposal introduces novel technologies that facilitate designing and manufacturing three-axis magnetic gradient coils for in vivo navigation of drug carrying particles in human arteries that are traceable by an MRI scanner. Developing a practical in vivo particle navigator can lead to very effective minimally invasive medical treatments, perhaps most importantly drug delivery to cancerous tissue. The NanoRobotics Laboratory Ecole Polytechnique Montreal (NLEPM) has demonstrated principles of image-based particle navigation by use of MRI hardware. Recent work by NLEPM, who is a collaborator in our proposed work, has indicated a need for magnetic field gradients strength of hundreds of mT/m to navigate micro-particle that can be used as carries of drugs. Our proposed Phase I work intends to demonstrate the feasibility of design and manufacturing of superconducting gradient coils that can achieve 500 mT/m, and which can be installed inside clinical human MRI scanners. PUBLIC HEALTH RELEVANCE: Our proposal introduces novel technologies that facilitate designing and manufacturing three-axis magnetic gradient coils for in vivo navigation of drug carrying particles in human arteries that are traceable by an MRI scanner. Developing a practical in vivo particle navigator can lead to very effective minimally invasive medical treatments, perhaps most importantly drug delivery to cancerous tissue.

描述（由申请人提供）：我们的提案介绍了有助于设计和制造三轴磁梯度线圈的新技术，用于人体动脉中携带药物的颗粒的体内导航，可通过MRI扫描仪跟踪。开发一种实用的体内粒子导航器可以带来非常有效的微创医学治疗，也许最重要的是将药物输送到癌组织。蒙特利尔理工大学纳米机器人实验室（NLEPM）通过使用MRI硬件演示了基于图像的粒子导航原理。NLEPM是我们的合作者，最近的工作表明，需要数百mT/m的磁场梯度来引导可以作为药物载体的微粒。我们提出的第一阶段工作旨在证明设计和制造超导梯度线圈的可行性，该线圈可以达到500 mT/m，并且可以安装在临床人体MRI扫描仪中。公共卫生相关性：我们的提案介绍了新技术，有助于设计和制造三轴磁梯度线圈，用于通过MRI扫描仪跟踪人体动脉中携带药物颗粒的体内导航。开发一种实用的体内粒子导航器可以带来非常有效的微创医学治疗，也许最重要的是将药物输送到癌组织。