权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Capsular Assemblies Driven by the Hydrophobic Effect

由疏水效应驱动的胶囊组件

基本信息

批准号：
7760945
负责人：
BRUCE C GIBB
金额：
$ 18.39万
依托单位：
UNIVERSITY OF NEW ORLEANS
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-02-01 至 2012-01-31
项目状态：
已结题

项目摘要

Project Summary The long-term objectives of this proposal are: 1) to learn how molecular structure and the hydrophobic effect combine to promote the assembly of nano-capsules in aqueous solution; 2) to use this information to both gain an understanding of quaternary protein structure, and devise self-assembling nano-capsules that function as drug delivery systems. The aim of this proposal is the synthesis and analysis of water-soluble cavitands that assemble into nano-scale capsules, and in doing so entrap guest molecules within their hollow interiors. Four cavitands that differ in cavity shape and size, and the area of hydrophobic surface that promotes assembly, will be synthesized. Each can be "coated" with an external layer of functionality that modulates their assembly properties. In combination these variables engenders hundreds of homo- and hetero-capsules. Capsule formation will be examined as a function of guest to determine how they influence assembly. In addition, we will examine how the capsules kinetically stabilize normally reactive compounds. Of particular interest in this regard will be the analysis of potential anti-malarial drugs that are too unstable or insoluble to individually demonstrate activity. Analysis of the systems will be carried out with Nuclear Magnetic Resonance (NMR) spectroscopy, Isothermal Titration Calorimetry (ITC), and fluorescence spectroscopy. Relevance The development of new drug delivery systems allows new avenues for attacking disease states. In mimicry of Nature's most efficient drug delivery systems- viruses - this proposal outlines investigations into the formation and properties of nano-capsules. To date, little is known about how nano-capsules assemble in water. Hence, these studies will provide valuable information pertaining to this novel field of research.

项目摘要这项提议的长期目标是：1)了解分子结构和疏水性效果结合以促进纳米胶囊在水溶液中的组装；2)利用这些信息来两人都了解了四元蛋白质的结构，并设计出了自组装纳米胶囊，起药物输送系统的作用。这项提议的目的是合成和分析可组装成纳米级的胶囊，在这样做的过程中，客体分子被困在其中空的内部。四个空洞空腔形状和大小不同，以及促进组装的疏水表面的面积将是合成的。每一种都可以用一层外层的功能来调节它们的组装属性。将这些变量结合在一起，就会产生数百个同质和异质胶囊。胶囊编队将作为客人的一项职能进行检查，以确定他们如何影响集会。此外, 我们将研究胶囊是如何动态稳定正常活性化合物的。特别感兴趣的在这方面，将对潜在的抗疟疾药物进行分析，这些药物太不稳定或无法溶解到个人展示活动。系统的分析将用核磁进行核磁共振光谱、等温滴定量热法和荧光光谱。相关性新药物输送系统的发展为攻击疾病状态提供了新的途径。在……里面模仿自然界最有效的药物传递系统--病毒--这项提案概述了研究研究纳米胶囊的形成和性质。到目前为止，人们对纳米胶囊是如何在水中组装。因此，这些研究将为这一新领域提供有价值的信息。研究。