Center Driven Research

中心驱动的研究

• 批准号: 8117303
• 负责人: Min Li
• 金额: $ 13.2万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8117303
• 关键词: Cardiotoxicity; Cells; Detection; Development; Evaluation; Ion Channel; Label; Molecular Bank; Research; Research Activity; Services; United States National Institutes of Health; Vision; base; programs; receptor; technology development

The vision of JHICC center-driven research is to perform projects that have an immediate impact on ion channel probe development and offer high value for the research activities of other Centers. This will greatly benefit the overall NIH-Molecular Library Programs (MLP). Here we propose two projects. The first project focuses on technology development. Specifically, we propose to develop cell-based label-free detection of ion channel and receptor activities. The second project focuses on a comprehensive service function by providing a high-level technical evaluation to predict compound cardiotoxicity. These two projects take advantage of our own expertise and should provide immediate benefit to both our own effort and the overall program of NIH network centers. 1. Cell-based label-free detection of ion channel and receptor activitiesrs. 2. Cardiac toxicity screen to evaluate compounds

JHICC中心驱动研究的愿景是执行对离子产生直接影响的项目 为其他中心的研究活动提供了很高的价值。这将大大 有利于整体NIH分子库计划（MLP）。在此，我们提出两个项目。第一个项目 专注于技术开发。具体而言，我们建议开发基于细胞的无标记检测， 离子通道和受体活性。第二个项目侧重于综合服务功能， 为预测化合物心脏毒性提供了高水平的技术评价。这两个项目 我们自己的专业知识的优势，并应提供立即有利于我们自己的努力和整体 美国国立卫生研究院网络中心。 1.基于细胞的离子通道和受体活性的无标记检测。 2.评估化合物的心脏毒性筛查