Developmental origins of BMI trajectory among adolescents

青少年体重指数轨迹的发展起源

基本信息

  • 批准号:
    7573611
  • 负责人:
  • 金额:
    $ 8.83万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-01-20 至 2010-12-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Obesity is poised to overtake tobacco as the greatest contributor to preventable death in the United States. Overweight children are at increased risk of being overweight as adults and are at increased risk of high morbidity related to a number of negative health outcomes (e.g., cardiovascular disease, diabetes, some cancers, and stroke). Risk factors for overweight and obesity start in early life, even prenatally although research that examines the longitudinal relationship between early life factors and obesity are sparse. We are particularly limited in our understanding of the influence of early life factors on individual overweight and obesity trajectories spanning over childhood, adolescence and early adulthood given the lack of repeated anthropomorphic measurements in most existing studies. We propose to examine the influence of prenatal and postnatal factors on BMI trajectory among youth transitioning from late childhood and adolescence into early adulthood. Given that obesity in childhood and adolescence increases risk for obesity in adulthood, research aimed at enhancing our understanding of potentially modifiable risk factors for an elevated BMI trajectory is important. To date most obesity research has failed to explore risk factors that explain patterns of BMI trajectory. Using a statistical analysis technique that is able to characterize groups of youth that express differential patterns of BMI over time-General Growth Mixture Modeling-this project will assess the impact of critical periods of exposure on obesity risk. These aims will be investigated using the Growing Up Today Study (GUTS), an ongoing longitudinal cohort study of 9,039 adolescent girls and 7,843 boys (aged 9-14 at baseline in 1996) who are offspring of mothers participating in the Nurses' Health Study II (NHS II). As a result, these datasets also allow for a unique opportunity to explore intergenerational predictors of obesity as well as the intersection of prenatal and postnatal factors, and childhood health behavior in explaining predictors of distinct trajectories of BMI during the transition from childhood to young adulthood. PUBLIC HEALTH RELEVANCE: The proposed study will use longitudinal cohort data (Growing Up Today Study) to investigate the influence of prenatal and postnatal factors on BMI trajectory among youth transitioning from late childhood and adolescence into early adulthood. The chosen outcome occurs with high prevalence in early life and influences a number of negative health outcomes (e.g., cardiovascular disease, diabetes, some cancers, stroke) throughout the life cycle. The central hypothesis is that adverse early life factors have both an independent and a cumulative impact on later weight trajectory but may be modified by lifestyles and behaviors. We will use growth mixture modeling to estimate the pattern of change in BMI across age beginning in late childhood to early adulthood and the relative influence of the pre- and post-natal factors and childhood behavior on the BMI trajectories. This novel analytic technique holds the promise of identifying distinct populations at risk for obesity and targeting critical time periods for long-term obesity prevention that may be unique to each subgroup.
描述(申请人提供):在美国,肥胖有望取代烟草,成为可预防死亡的最大因素。超重儿童成年后超重的风险增加,与一些负面健康后果(例如心血管疾病、糖尿病、某些癌症和中风)相关的高发病率风险增加。超重和肥胖的风险因素开始于早期生活,甚至是产前,尽管研究早期生活因素与肥胖之间纵向关系的研究很少。鉴于大多数现有研究缺乏重复的拟人化测量,我们对早期生活因素对跨越童年、青春期和成年早期的个人超重和肥胖轨迹的影响的理解尤其有限。我们建议检查出生前和出生后因素对从儿童后期和青春期过渡到成年早期的青年BMI轨迹的影响。鉴于儿童和青春期肥胖会增加成年后肥胖的风险,旨在加强我们对BMI上升轨迹的潜在可改变风险因素的理解的研究是重要的。到目前为止,大多数肥胖症研究都未能探索出解释BMI轨迹模式的风险因素。使用一种统计分析技术,能够表征随着时间的推移表现出不同BMI模式的青年群体--通用生长混合模型--该项目将评估暴露于关键时期对肥胖风险的影响。这些目标将通过“今日成长研究”(GUTS)进行调查,这是一项正在进行的纵向队列研究,涉及9039名青春期女孩和7843名男孩(1996年基线年龄为9-14岁),他们是参加第二次护士健康研究(NHS II)的母亲的后代。因此,这些数据集还提供了一个独特的机会来探索肥胖的代际预测因素,以及产前和出生后因素的交集,以及儿童健康行为,以解释从童年到成年的转变过程中体重指数的不同轨迹的预测因素。 公共卫生相关性:这项拟议的研究将使用纵向队列数据(Growing Up Today Study)来调查从儿童后期和青春期过渡到成年早期的青少年中产前和出生后因素对BMI轨迹的影响。所选择的结果在生命早期发病率很高,并在整个生命周期中影响一些负面的健康结果(例如,心血管疾病、糖尿病、某些癌症、中风)。中心假设是,不利的早期生活因素对后来的体重轨迹既有独立的影响,也有累积的影响,但可能会被生活方式和行为改变。我们将使用生长混合模型来估计从儿童后期到成年早期BMI的年龄变化模式,以及出生前和出生后因素以及儿童行为对BMI轨迹的相对影响。这一新的分析技术有望识别不同的肥胖风险人群,并针对可能针对每个亚群的长期肥胖预防的关键时间段。

项目成果

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Hee-Jin Jun其他文献

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{{ truncateString('Hee-Jin Jun', 18)}}的其他基金

Developmental origins of BMI trajectory among adolescents
青少年体重指数轨迹的发展起源
  • 批准号:
    7760035
  • 财政年份:
    2009
  • 资助金额:
    $ 8.83万
  • 项目类别:

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