The Role of Hippo Pathway in Liver Regeneration

描述（由申请人提供）：肝病是美国十大死亡原因之一。肝脏非凡的再生能力对于理解导致发育缺陷、急性和慢性肝病以及肝癌发生的机制至关重要。刺激肝细胞增殖同时防止细胞凋亡对于肝脏的再生过程是必不可少的。最近，我们发现了一个肿瘤抑制途径对肝细胞分裂和死亡具有强大的影响。我们的长期目标是确定健康和疾病中肝再生的细胞机制，并将这些发现应用于开发肝脏疾病的改进疗法。为此，我们有独特的能力来解决这个应用程序的目标，这是揭示机制，导致新的肿瘤抑制剂对肝脏的深刻影响。这一建议的中心假设是：肿瘤抑制因子控制肝细胞生长因子途径控制肝脏大小。在研究结束时，我们将更好地了解肝细胞的生长和死亡。这将有助于开发许多肝脏疾病的治疗方法，如肝移植，肝硬化，急性和慢性肝炎。

DESCRIPTION (provided by applicant): Liver diseases are among the 10 leading causes of death in the United States. The liver's extraordinary regenerative capacity is critical to understanding the mechanisms leading to developmental defects, acute and chronic liver diseases, and liver carcinogenesis. Stimulation of hepatocyte proliferation while preventing apoptosis is essential to the liver's regenerative process. Recently we uncovered a tumor suppressor pathway has potent effects upon liver cell division and death. Our long range goal is to define the cellular mechanisms underlying liver regeneration in health and disease and to apply these findings to developing improved therapies for liver disease. To that end, we are uniquely capable to address the objectives of this application, which are to uncover the mechanism that leads to the novel tumor suppressors' profound effects upon the liver. The central hypothesis of this proposal is that: The tumor suppressor controls liver celgrowth factor pathway in controlling liver size. At the end of the study we will better understand the growth and death of liver cells. This will help develop treatment for many liver diseases such as liver transplantation, cirrhosis, acute and chronic hepatitis.