Pathology Core

项目摘要 这一共享资源的目的是提供人体组织、生物液体和专家病理学检查。 为项目调查人员提供口译服务。病理学核心将与现有资源GI孢子一起工作 组织库，这是根据同一董事（博士R。Anders）作为该拟议病理学核心，建立一个 收集适当储存的肝脏组织和生物液体。组织样本的范围从福尔马林- 来自肝移植标本的固定石蜡包埋和冷冻组织， 临床数据。该病理学核心将从肝脏中收集高质量的快速冷冻和福尔马林固定样本 移植患者生物标本将根据国家癌症研究所的要求进行采集和储存。 生物储存库最佳实践指南。将这些标本分发给项目调查人员 将由病理学中心主任协调。该CORE将在以下人员的监督下采购标本： 一位具有肝脏病理学专业知识的病理学家，与外科医生密切合作， 肝病学家和基础研究调查人员，以最大限度地提高项目的翻译影响。这一拟议 CORE将利用现有的数据库框架、样本分配和优先排序系统， 源自现有的孢子。具体来说，我们将在一个 密码保护的数据库。将建立一个机制，优先分发所要求的 约翰霍普金斯医疗系统内部和外部的研究人员的资源。

PROJECT SUMMARY The purpose of this shared resource is to provide human tissues, biological fluids, and expert pathologic interpretation for project investigators. The Pathology Core will work with an existing resource, the GI SPORE Tissue Bank, which is under the same director (Dr. R. Anders) as this proposed Pathology Core, to establish a collection of properly banked liver tissue and biological fluids. The tissue samples will range from formalin- fixed paraffin-embedded and frozen tissues available from liver transplantation specimens which will be linked to clinical data. This Pathology Core will collect high quality snap frozen and formalin fixed samples from liver transplant patients. The biospecimens will be harvested and banked in accordance with the National Cancer Institute’s Best Practice Guidelines for Biorepositories. Distribution of these specimens to project investigators will be coordinated by the Pathology Core director. This CORE will procure specimens under the supervision of a pathologist with expertise in hepatopathology and in close collaboration with surgeons, transplant hepatologists and basic research investigators to maximize translational impact of the projects. This proposed CORE will leverage existing database framework, specimen distribution and prioritization systems that originated from existing SPORES. Specifically, we will have clinical histories linked to pathologic data in a password protected database. A mechanism will be in place for prioritization of distribution of requested resources to investigators within and external to the Johns Hopkins Medical System.