Pathology Core

项目总结 这个共享资源的目的是提供人体组织、生物液和专家病理学 为项目调查人员提供口译。病理核心将与现有的资源，胃肠道孢子一起工作 组织银行，与拟议的病理学核心由同一主管(R.安德斯博士)领导，以建立一个 收集适当储存的肝组织和生物液。组织样本的范围从福尔马林- 来自肝移植标本的固定石蜡包埋和冰冻组织将被连接 临床数据。这个病理核心将从肝脏收集高质量的快速冷冻和福尔马林固定的样本 移植病人。生物标本将按照国家癌症研究所的要求进行收获和储存 该研究所的生物信息库最佳实践指南。将这些标本分发给项目调查人员 将由病理核心主管协调。该岩芯将在监督下获取标本 一位在肝脏病理学方面有专长并与外科医生密切合作的病理学家，移植 肝病专家和基础研究人员，以最大限度地发挥项目的翻译影响。这项建议 CORE将利用现有的数据库框架、样本分发和优先排序系统 起源于现有的孢子。具体地说，我们将在一个 受密码保护的数据库。将建立一个机制，确定请求分配的优先顺序 为约翰·霍普金斯医疗系统内外的研究人员提供资源。

PROJECT SUMMARY The purpose of this shared resource is to provide human tissues, biological fluids, and expert pathologic interpretation for project investigators. The Pathology Core will work with an existing resource, the GI SPORE Tissue Bank, which is under the same director (Dr. R. Anders) as this proposed Pathology Core, to establish a collection of properly banked liver tissue and biological fluids. The tissue samples will range from formalin- fixed paraffin-embedded and frozen tissues available from liver transplantation specimens which will be linked to clinical data. This Pathology Core will collect high quality snap frozen and formalin fixed samples from liver transplant patients. The biospecimens will be harvested and banked in accordance with the National Cancer Institute’s Best Practice Guidelines for Biorepositories. Distribution of these specimens to project investigators will be coordinated by the Pathology Core director. This CORE will procure specimens under the supervision of a pathologist with expertise in hepatopathology and in close collaboration with surgeons, transplant hepatologists and basic research investigators to maximize translational impact of the projects. This proposed CORE will leverage existing database framework, specimen distribution and prioritization systems that originated from existing SPORES. Specifically, we will have clinical histories linked to pathologic data in a password protected database. A mechanism will be in place for prioritization of distribution of requested resources to investigators within and external to the Johns Hopkins Medical System.