Origins and properties of dental stem cells

牙齿干细胞的起源和特性

• 批准号: G0600041/1
• 负责人: Paul Sharpe
• 金额: $ 45.41万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0600041%2F1
• 关键词: Origins; properties; dental; stem; cells

Stem cells have an enormous potential for offering new clinical treatments of a wide variety of diseases and disorders because of their ability to form many different types of cells. Research on stem cells is currently focussed into two main general areas: 1. The use of embryonic stem cells (ES). 2. The use of adult stem cells.Embryonic stem cells are an attractive source because they are easy to grow and are capable of producing all cell types in the body. The main problem with ES cells is that they can only be derived from early stage embryos and obtaining these cells from each individual patient is not feasible. Without being able to do this any ES cell therapy may require immune suppression to avoid rejection.Adult stem cells are populations of cells that are found in many different tissues and organs of the body, including the intestine, bone marrow, hair and skin. These cells offer a major advantage for clinical use since they can be obtained from each patient and thus would not be rejected by the immune system. The problems with adult stem cells are that they are often present in small numbers and their ability to form different cell types varies depending on the tissue source. The ideal source of stem cells is one where the cells are easily and repeatedly accessible, can be easily cultured in vitro and their differentiation potentials are known and can be manipulated. Currently there is no single source of stem cells that satisfies these criteria. Stem cells have been recently identified in teeth, both from adults and from milk teeth naturally lost by children. Teeth may offer a source of stem cells that can be easily obtained and because children naturally lose up to 20 milk teeth, there is the potential of having 20 opportunities to bank these cells for future use. At present however very little is known about these stem cells and the aim of this project therefore is to investigate where these cells come from, and to study what cell types they are able to form. This research will determine how usable these cells will be for clinical therapies and will also provide the reagents for identifying and purifying dental stem cells from patients teeth.

干细胞具有巨大的潜力，因为它们能够形成许多不同类型的细胞，为各种疾病和病症提供新的临床治疗。干细胞的研究目前集中在两个主要领域：1。胚胎干细胞（ES）的应用2.成体干细胞的使用。胚胎干细胞是一种有吸引力的来源，因为它们易于生长，并且能够在体内产生所有类型的细胞。胚胎干细胞的主要问题是它们只能来自早期胚胎，从每个患者身上获得这些细胞是不可行的。成体干细胞是一种存在于人体不同组织和器官中的细胞群，包括肠道、骨髓、毛发和皮肤。成体干细胞是一种具有多种细胞类型的细胞，可以在人体的不同组织和器官中找到。这些细胞为临床应用提供了一个主要优势，因为它们可以从每个患者身上获得，因此不会被免疫系统排斥。成体干细胞的问题在于它们通常存在于少量中，并且它们形成不同细胞类型的能力取决于组织来源。理想的干细胞来源是细胞容易和重复获得，可以容易地在体外培养，并且它们的分化潜能是已知的并且可以被操纵。目前还没有一个单一的干细胞来源满足这些标准。最近在牙齿中发现了干细胞，这些干细胞来自成人和儿童自然脱落的乳牙。牙齿可以提供一个很容易获得的干细胞来源，因为儿童自然会失去多达20颗乳牙，因此有可能有20个机会将这些细胞储存起来供未来使用。然而，目前对这些干细胞知之甚少，因此该项目的目的是调查这些细胞来自哪里，并研究它们能够形成什么样的细胞类型。这项研究将确定这些细胞在临床治疗中的可用性，并将为从患者牙齿中识别和纯化牙齿干细胞提供试剂。