Uniquely high conversion and mechanically robust composite restorative materials for functionally elevated performance

独特的高转化率和机械坚固的复合修复材料，可提高功能性能

• 批准号: 10646845
• 负责人: JEFFREY W. STANSBURY
• 金额: $ 44.15万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-05 至 2025-09-04
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10646845
• 关键词: 3-Dimensional; 3D Print; Acids; Address; Affect; Behavior; Bisphenol A-Glycidyl Methacrylate; Carboxylic Acids; Ceramics; Characteristics; Chemicals; Clinical; Consumption; Data; Degree Completion; Dental; Dental Materials; Dental caries; Dentistry; Dentists; Development; Elasticity; Esthetics; Evaluation; Evolution; Exhibits; Failure; Filler; Formulation; Fracture; Future; Hardness; Hydrogen Bonding; Link; Lithium; Longevity; Mechanics; Methacrylates; Modulus; Nature; Pathway interactions; Peer Review; Performance; Phase; Pilot Projects; Plant Resins; Polymers; Positive Reinforcements; Process; Property; Publishing Peer Reviews; Reaction; Recovery; Recurrence; Refractive Indices; Reporting; Residual state; Resistance; Stress; Structure; System; Techniques; Temperature; Testing; Time; Tooth Fractures; Tooth structure; Urethane; Visible Radiation; Work; allergic response; biomaterial compatibility; carboxylate; carboxylation; composite restoration; copolymer; crosslink; cytotoxicity; design; expectation; improved; innovation; mechanical properties; methacrylic acid; molecular assembly/self assembly; monomer; novel; photocuring; photopolymerization; polymerization; polymerization shrinkage; polymerization stress; repaired; resilience; restoration; restorative composite; restorative dentistry; restorative material; screening; standard of care; trait; virtual

The hydrogen bonding interactions in BisGMA and urethane dimethacrylate (UDMA) based resins provides positive reinforcement to polymer networks that enhance overall strength. In this study, we are taking the noncovalent interactions involving urethane functionality to an elevated level by preferentially inserting urethane-carboxylate hydrogen bonding interactions and designing novel copolymers that reach near quantitative conversion during a brief ambient temperature photopolymerization. The highly converted polymer also displays extremely high modulus, strength and toughness. The proposed project will investigate the structure-property relationships that allow this unusual combination of polymer properties to coexist while also developing a fundamental understanding of the mechanism by which it occurs. The addition of filler to these interesting resins will provide novel materials with substantially higher performance than existing composites. negligible leachable free monomer and extreme mechanical strength combined with exceptional toughness. Based on the hypothesis of a latent onset of polymeric vitrification following complete conversion, the expectation is that polymerization stress will be quite low, which will be assessed. An unfilled polymer with structure related to the central materials to be developed here demonstrated dramatically increased wear resistance compared to both unfilled and filled commercial dental polymers and even out-performed a lithium disilicate ceramic. Since the self-reinforced polymers involved here offer even greater strength, higher modulus and more extensive toughness and resilience, we anticipate that the filled version of these materials will promote even more impressive wear behavior. As the project progresses, biocompatibility using both direct contact and elution testing will be in place to assure that only viable composite materials will be advanced. A mechanically robust composite that does not leach unreacted monomer because the monomers are fully consumed during polymer network formation has potential to mitigate the current concerns of both composite fracture and secondary caries, which together account for the large majority of failures of resin-based composite restorations. The pilot project proposed here will identify and validate practical candidate materials as a new class of composite restoratives that represent a non-incremental advance in this field upon which the current and future practice of dentistry remains so reliant. The comprehensive nature of the analytical characterization involved here relies on previously peer-reviewed published techniques that meet the challenge of rigor.

基于BisGMA和氨基甲酸酯二甲基丙烯酸酯（UDMA）的树脂中的氢键相互作用提供了 对聚合物网络的正增强，增强整体强度。在这项研究中，我们将 涉及氨基甲酸酯官能度的非共价相互作用， 羧酸酯氢键相互作用和设计达到近 在短暂的环境温度光聚合期间的定量转化。高度转化的聚合物 还显示出极高的模量、强度和韧性。拟议项目将调查 结构-性能关系，允许这种不寻常的聚合物性能组合共存，同时还 对它发生的机制有了基本的了解。添加填料到这些 令人感兴趣的树脂将提供具有比现有复合材料高得多的性能的新型材料。 可忽略不计的可沥滤游离单体和极高的机械强度以及优异的韧性。 基于完全转化后聚合物玻璃化的潜在开始的假设， 预期聚合应力将相当低，这将被评估。一种未填充的聚合物， 与这里将要开发的中心材料相关的结构显示出显著增加的磨损 与未填充和填充的商业牙科聚合物相比， 二硅酸盐陶瓷由于这里涉及的自增强聚合物提供更大的强度，更高的模量 以及更广泛的韧性和弹性，我们预计，这些材料的填充版本将促进 更令人印象深刻的磨损行为。随着项目的进展，使用直接接触和 将进行洗脱测试，以确保仅推进可行的复合材料。机械 不浸出未反应的单体的坚固复合材料，因为单体在聚合过程中被完全消耗。 聚合物网络的形成有可能减轻目前对复合材料断裂和 继发性龋，它们共同导致了树脂基复合材料修复的大部分失败。 这里提出的试点项目将确定和验证实用的候选材料，作为一个新的类别， 复合材料，代表了这一领域的非增量进步，目前和未来 牙科的实践仍然如此依赖。所涉及的分析表征的全面性 这里依赖于以前同行评审的已发表的技术，以满足严格的挑战。