Primary Care Provider Education on Common Disease Genetics

初级保健提供者常见疾病遗传学教育

• 批准号: 7742730
• 负责人: Ethylin Wang Jabs
• 金额: $ 58.7万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7742730
• 关键词: Academy; Address; Adult; Age related macular degeneration; Aging; American; Attitude; Awareness; Belief; Case Study; Chronic; Clinic; Clinical; Communication; Communication Tools; Complex; Data; Development; Discipline; Disease; Education; Effectiveness; Endocrinology; Epidemiologist; Exercise; Family; Family Physicians; General Practitioners; Genetic; Genetic Markers; Genetic Risk; Genetic Variation; Genetic screening method; Genomics; Goals; Grant; Health Communication; Health Professional; Healthcare; Helping Behavior; Hereditary Disease; Institution; Internal Medicine; Internist; Intervention; Interview; Lead; Life; Macular degeneration; Malignant neoplasm of prostate; Measures; Medical; Medical Genetics; Medicine; Multimedia; Non-Insulin-Dependent Diabetes Mellitus; Onset of illness; Ophthalmology; Outcome; Patients; Physicians; Population; Predisposition; Primary Care Physician; Primary Health Care; Process; Professional Education; Professional counselor; Provider; Psychologist; Questionnaires; Randomized Controlled Trials; Research Personnel; Risk; Science; Surveys; Testing; Training; Universities; age related; cancer type; clinical practice; clinically significant; communication aid; design; genome wide association study; improved; innovation; medical schools; meetings; member; oncology; programs; response; skills; therapy design

DESCRIPTION (provided by applicant): Primary care providers (PCPs), especially physicians, are becoming increasingly responsible for advising patients regarding common disease genetic testing. Genome-wide association studies (GWASs) have identified common gene variants which are associated with a range of common adult-onset diseases, such as age-related macular degeneration, prostate cancer and type II diabetes. The clinical significance of these GWAS results remains unclear and controversial. However, commercial companies are already offering direct-to-consumer genetic tests for common diseases using these findings. In order to be prepared for patient inquiries about these tests and perhaps the eventual integration of genomics into their clinical practice, PCPs need to be able to understand, evaluate and communicate with their patients about GWAS findings, genetic risk and genetic tests. At present, the evidence suggests that PCPs are not prepared for these genomic developments. The overall objectives of this study are to: (1) effectively educate PCPs to evaluate genetic information and incorporate it only when appropriate into their clinical practice; and (2) improve provider-patient communication about genomics and genetic testing. To achieve these goals, the specific aims are to: 1) conduct a survey of physicians through the American Association of Family Practitioners (AAFP) and the American Board of Internal Medicine (ABIM), interviews with PCPs, and meetings among expert consultants to inform the design, content and development of an intervention designed to educate PCPs about common disease genetics and genetic testing; 2) develop and pilot the intervention components such as case study vignettes, communication videos, and handheld risk communication aids; and 3) plan a randomized controlled trial (RCT) using the educational and communication intervention to evaluate its effectiveness in improving PCPs' understanding and communication of common disease genetics. This planning grant will involve diverse healthcare settings at Mount Sinai School of Medicine, Mayo Clinic, and Duke University to understand PCPs' current beliefs, attitudes and understanding of genomics and genetic testing, and whether an innovative multimedia intervention can change their behavior and help them effectively communicate information about genetics of common diseases.

描述（由申请人提供）： 初级保健提供者（PCP），尤其是医生，越来越多地为患者提供有关常见疾病基因检测的建议。全基因组关联研究（GWASS）已经确定了与一系列常见的成人发作疾病有关的常见基因变异，例如与年龄相关的黄斑变性，前列腺癌和II型糖尿病。这些GWAS结果的临床意义尚不清楚和有争议。但是，商业公司已经在使用这些发现为常见疾病提供直接面向消费者的基因检测。为了准备有关这些测试的患者询问，也许是将基因组学最终整合到其临床实践中，PCP需要能够了解，评估，评估和沟通有关GWAS发现，遗传风险和遗传测试的情况。目前，有证据表明未为这些基因组发展准备PCP。这项研究的总体目标是：（1）有效教育PCP，以评估遗传信息并仅在适当的临床实践中纳入遗传信息； （2）改善有关基因组学和基因检测的提供者的患者沟通。为了实现这些目标，具体的目的是：1）通过美国家庭从业人员协会（AAFP）和美国内科医学委员会（ABIM）对医师进行调查，对PCP的访谈以及专家顾问之间的会议，以告知旨在教育PCP关于常见疾病遗传学和遗传测试的干预措施的设计，内容和开发； 2）开发和试行干预组件，例如案例研究 小插图，沟通视频和手持式风险通信辅助工具； 3）使用教育和交流干预措施计划一项随机对照试验（RCT），以评估其在改善PCP的理解和传播常见疾病遗传学方面的有效性。该计划赠款将涉及西奈山医学院，梅奥诊所和杜克大学的多样化医疗机构，以了解PCP当前的信念，态度和对基因组学和基因检测的理解，以及创新的多媒体干预是否可以改变其行为并帮助他们有效地传达有关常见疾病基因的信息。