Interdisciplinary Training in Systems and Developmental Biology and Birth Defects

系统与发育生物学和出生缺陷的跨学科培训

• 批准号: 10159749
• 负责人: Ethylin Wang Jabs
• 金额: $ 19.01万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10159749
• 关键词: Congenital Abnormality; Developmental Biology; Systems Biology; Training

ABSTRACT Systems biology is a relatively new discipline used to understand the complex interactions underlying healthy and diseased states of a cell, tissue, or organism, requiring knowledge of networks of processes and molecular and protein interactions within and among cells, organs, and an organism as a whole. Studies of normal development and birth defects are more established classical disciplines. The integration of systems biologic approaches to the study of normal development and inborn errors of development is emerging. Scientists who are versed in both mathematics and biology are needed to address the complexities of development biology by examining the thousands to millions of factors and events that occur simultaneously in a temporospatial and quantitative manner during the lifetime of an organism. Thus, to promote cross-training in these disciplines, we are submitting a competitive renewal application to continue the integrated training program, “Interdisciplinary Training in Systems and Developmental Biology and Birth Defects” at the Icahn School of Medicine at Mount Sinai in New York City. During the past four years and one month, we successfully built a program that includes 35 faculty members from 8 different departments, 4 institutes, and 4 multidisciplinary training areas (Developmental and Regenerative Biology, Neurosciences, Genetics and Genomics Sciences, and Biophysics and Systems Pharmacology) of the Graduate School of Biological Sciences at Mount Sinai. An outstanding group of educators and scientists with expertise in systems biology, developmental biology or birth defects, including the Directors and members of the External Advisory, Executive Faculty, and Curriculum Committees, provide the leadership, administration, and mentorship for the program. The Curriculum emphasizes the integration of concepts of developmental biology, inborn errors of development, genomics, molecular biology, biochemistry, physiology, pharmacology, quantitative reasoning, computational biology, and bioinformatics. We have created novel courses, journal clubs, and seminar series combining principles of systems biology, developmental biology and birth defects in order to enhance the unique learning experience. The institutional infrastructure for commitment and enhancement of diversity; selection of potential candidates; recruitment; facilities and resources; training in responsible conduct of research and enhancing reproducibility; support for career development; and training program evaluations are already existent for this training program. To date, we have supported 13 PhD or MD/PhD candidates for 1 to 2 years on this training grant; 3 trainees have gone on to receive their individual NIH F30 or 31 awards, and 3 trainees have graduated and are accepted into excellent postdoctoral training programs. Our predoctoral program provides exciting and unique opportunities for study from genomes and proteins to cells, animal models, and humans at the bench and the bedside. The continuation of this innovative training will undoubtedly produce much needed scientists poised at the frontiers of both computational and developmental biology.

抽象的 系统生物学是一门相对较新的学科，用于了解健康背后的复杂相互作用 以及细胞、组织或生物体的疾病状态，需要过程和分子网络的知识 以及细胞、器官和整个有机体内部和之间的蛋白质相互作用。正常人的研究 发育和出生缺陷是更为成熟的经典学科。系统生物集成 研究正常发育和先天性发育错误的方法正在出现。科学家们 需要精通数学和生物学来解决发育生物学的复杂性 检查时空和空间中同时发生的数千到数百万个因素和事件 生物体一生中的定量方式。因此，为了促进这些学科的交叉培训，我们 正在提交竞争性更新申请，以继续综合培训计划“跨学科 伊坎医学院系统与发育生物学和出生缺陷培训” 纽约市的西奈山。在过去的四年零一个月里，我们成功地建立了一个项目 包括来自8个不同部门、4个研究所和4个多学科培训领域的35名教职人员 （发育和再生生物学、神经科学、遗传学和基因组学以及生物物理学 和系统药理学）西奈山生物科学研究生院。一个杰出的 由具有系统生物学、发育生物学或出生缺陷专业知识的教育工作者和科学家组成的群体， 包括外部顾问、执行教师和课程委员会的董事和成员， 为该计划提供领导、管理和指导。课程强调 发育生物学、先天性发育错误、基因组学、分子生物学概念的整合， 生物化学、生理学、药理学、定量推理、计算生物学和生物信息学。我们 创建了结合系统生物学原理的新颖课程、期刊俱乐部和研讨会系列， 发育生物学和出生缺陷，以增强独特的学习体验。机构 承诺和加强多样性的基础设施；选择潜在候选人；招聘; 设施和资源；负责任地进行研究和提高可重复性的培训；支持 职业发展；并且该培训计划的培训计划评估已经存在。迄今为止， 我们已通过此项培训补助金为 13 名博士或医学博士/博士生提供了 1 至 2 年的支持； 3名实习生已离去 获得个人 NIH F30 或 31 奖项，3 名学员已毕业并被录取 优秀的博士后培养项目。我们的博士前课程提供令人兴奋和独特的机会 用于在实验室和床边进行从基因组和蛋白质到细胞、动物模型和人类的研究。这 继续这种创新培训无疑将培养出急需的处于前沿的科学家 计算生物学和发育生物学。