Interdisciplinary Training in Systems and Developmental Biology and Birth Defects

系统与发育生物学和出生缺陷的跨学科培训

• 批准号: 10159749
• 负责人: Ethylin Wang Jabs
• 金额: $ 19.01万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10159749
• 关键词: Congenital Abnormality; Developmental Biology; Systems Biology; Training

ABSTRACT Systems biology is a relatively new discipline used to understand the complex interactions underlying healthy and diseased states of a cell, tissue, or organism, requiring knowledge of networks of processes and molecular and protein interactions within and among cells, organs, and an organism as a whole. Studies of normal development and birth defects are more established classical disciplines. The integration of systems biologic approaches to the study of normal development and inborn errors of development is emerging. Scientists who are versed in both mathematics and biology are needed to address the complexities of development biology by examining the thousands to millions of factors and events that occur simultaneously in a temporospatial and quantitative manner during the lifetime of an organism. Thus, to promote cross-training in these disciplines, we are submitting a competitive renewal application to continue the integrated training program, “Interdisciplinary Training in Systems and Developmental Biology and Birth Defects” at the Icahn School of Medicine at Mount Sinai in New York City. During the past four years and one month, we successfully built a program that includes 35 faculty members from 8 different departments, 4 institutes, and 4 multidisciplinary training areas (Developmental and Regenerative Biology, Neurosciences, Genetics and Genomics Sciences, and Biophysics and Systems Pharmacology) of the Graduate School of Biological Sciences at Mount Sinai. An outstanding group of educators and scientists with expertise in systems biology, developmental biology or birth defects, including the Directors and members of the External Advisory, Executive Faculty, and Curriculum Committees, provide the leadership, administration, and mentorship for the program. The Curriculum emphasizes the integration of concepts of developmental biology, inborn errors of development, genomics, molecular biology, biochemistry, physiology, pharmacology, quantitative reasoning, computational biology, and bioinformatics. We have created novel courses, journal clubs, and seminar series combining principles of systems biology, developmental biology and birth defects in order to enhance the unique learning experience. The institutional infrastructure for commitment and enhancement of diversity; selection of potential candidates; recruitment; facilities and resources; training in responsible conduct of research and enhancing reproducibility; support for career development; and training program evaluations are already existent for this training program. To date, we have supported 13 PhD or MD/PhD candidates for 1 to 2 years on this training grant; 3 trainees have gone on to receive their individual NIH F30 or 31 awards, and 3 trainees have graduated and are accepted into excellent postdoctoral training programs. Our predoctoral program provides exciting and unique opportunities for study from genomes and proteins to cells, animal models, and humans at the bench and the bedside. The continuation of this innovative training will undoubtedly produce much needed scientists poised at the frontiers of both computational and developmental biology.

抽象的 Systems Biology是一种相对的新学科，用于了解健康基础的复杂互动 细胞，组织或生物体的患病状态，需要了解过程网络和分子网络 细胞，器官和整个生物体内外的蛋白质相互作用。正常研究 发展和先天缺陷是更确定的古典学科。系统生物学的整合 正常发展和天生发展错误的研究正在出现。科学家谁 需要精通数学和生物学，以解决发展生物学的复杂性 检查仅在暂时空间中发生的数千个因素和事件 生物体一生中的定量方式。为了促进这些学科的交叉训练，我们 正在提交竞争性更新申请，以继续综合培训计划，“跨学科 伊坎医学院的系统和发育生物学和出生缺陷的培训 纽约市西奈山。在过去的四年零一个月中，我们成功构建了一个计划 包括来自8个不同部门的35名教职员工，4个机构和4个多学科培训领域 （发展和再生生物学，神经科学，遗传学和基因组学以及生物物理学 西奈山生物科学研究生院的系统药理学）。杰出 一群教育者和科学家在系统生物学，发育生物学或先天缺陷方面具有专业知识， 包括外部咨询，执行教师和课程委员会的董事和成员， 为该计划提供领导，管理和指导。课程强调 发育生物学概念的整合，天生的发展错误，基因组学，分子生物学， 生物化学，生理学，药理学，定量推理，计算生物学和生物信息学。我们 创建了新颖的课程，期刊俱乐部和开创性系列，结合了系统生物学原理， 发育生物学和先天缺陷，以增强独特的学习经验。机构 承诺和增强多样性的基础设施；选择潜在的候选人；招聘; 设施和资源；负责任进行研究和增强可重复性的培训；支持 职业发展；该培训计划已经存在和培训计划评估。迄今为止， 我们已经在这项培训补助金上为1至2年的1至2年提供了1至2年的支持； 3名学员走了 继续获得其个人NIH F30或31个奖项，3名学员已毕业并被接受 出色的博士后培训计划。我们的专用计划提供了令人兴奋和独特的机会 从基因组和蛋白质到细胞，动物模型和人类的研究。这 这种创新培训的延续无疑会导致在边境中毒的急需的科学家 计算和发展生物学。