Interdisciplinary Training in Systems and Developmental Biology and Birth Defects

描述（由申请人提供）：系统生物学是一门相对较新的学科，用于理解细胞，组织或生物体健康和患病状态下的复杂相互作用，需要了解细胞，器官和生物体整体内部和之间的过程网络以及分子和蛋白质相互作用。正常发育和出生缺陷的研究是更为成熟的经典学科。然而，到目前为止，很少有系统生物学的方法来研究发育和先天发育错误。需要精通数学和生物学的科学家通过检查生物体一生中以时空和定量方式同时发生的成千上万的因素和事件来解决发育生物学的复杂性。因此，为了填补在这些多学科培训的科学家的空白，我们提出了一个新的综合培训计划，“系统和发育生物学和出生缺陷的跨学科培训”在西奈山医学院，它有承诺和基础设施来管理一个成功和严格的教育计划。整个组织包括来自12个不同部门、研究所和中心的至少28名教师，以及3个多学科培训领域（发育和再生生物学、遗传学和基因组学科学、系统生物学和疾病治疗学）和生物科学研究生院。一群在系统生物学、发育生物学或先天缺陷方面具有专业知识的杰出科学家和教育工作者将担任主任、联合主任以及外部咨询委员会、执行教员委员会和课程委员会的成员，他们将为该计划提供领导和管理。课程将强调发育生物学、先天发育错误、基因组学、分子生物学、生物化学、生理学、药理学等概念的整合；定量推理，计算生物学和生物信息学。此外，新的课程模块、期刊俱乐部和系列研讨会将整合系统生物学、发育生物学和出生缺陷，以增强独特的学习体验。培训项目评估的基础设施；潜在候选人的选择；制度环境、承诺和资源；招聘和保留；计划加强多样性；和负责任的研究行为的培训已经存在于其他美国国立卫生研究院资助的西奈山培训项目中，可以应用于这个新项目。该项目将在紧密结合的医学院和医院环境中进行，为从基因组和蛋白质到细胞到动物模型再到临床和床边的人类研究提供令人兴奋和独特的机会。这种拟议的培训无疑将培养未来的科学家，为系统和发育生物学的新前沿做好准备。

DESCRIPTION (provided by applicant): Systems biology is a relatively new discipline used to understand the complex interactions underlying healthy and diseased states of a cell, tissue, or organism, requiring knowledge of networks of processes and molecular and protein interactions within and among cells, organs, and an organism as a whole. Studies of normal development and birth defects are more established classical disciplines. However to date, there has been very little integration of system biologic approaches to the study of development and inborn errors of development. Scientists who are versed in both mathematics and biology are needed to address the complexities of development biology by examining the thousands to millions of factors and events that occur simultaneously in a temporospatial and quantitative manner during the lifetime of an organism. Thus, to fill the void of scientists trained in these multiple disciplnes, we propose a new and integrated training program, "Interdisciplinary Training in Systems and Developmental Biology and Birth Defects" at Mount Sinai School of Medicine, which has the commitment and infrastructure to administer a successful and rigorous educational program. The overall organization includes at least 28 faculty from 12 different departments, institutes, and centers as well as 3 multidisciplinary training areas (Developmental and Regenerative Biology, Genetics and Genomics Sciences, and Systems Biology and Disease Therapeutics) and the Graduate School of Biological Sciences. An outstanding group of scientists and educators with expertise in systems biology, developmental biology or birth defects, will be the Director, co-Directors, and the members of the External Advisory Committee, Executive Faculty Committee, and the Curriculum Committee, who will provide the leadership and administration for the program. The Curriculum will emphasize the integration of concepts of developmental biology, inborn errors of development, genomics, molecular biology, biochemistry, physiology, pharmacology; and quantitative reasoning, computational biology, and bioinformatics. In addition, new course modules, journal clubs, and seminar series integrating systems biology, developmental biology and birth defects will be created to enhance the unique learning experience. The infrastructure of the training program evaluation; selection of potential candidates; institutional environment, commitment and resources; recruitment and retention; plan to enhance diversity; and training in responsible conduct of research are already existent for other NIH-funded training programs at Mount Sinai and can be applied to this new program. The program, which will be set within a tightly knit medical school and hospital environment, provides exciting and unique opportunities for study from genomes and proteins to cells to animal models to humans at the bench and the bedside. This proposed training will undoubtedly produce future scientists ready for the new frontier of systems and developmental biology.