Interdisciplinary Training in Systems and Developmental Biology and Birth Defects

系统与发育生物学和出生缺陷的跨学科培训

• 批准号: 8640965
• 负责人: Ethylin Wang Jabs
• 金额: $ 18.14万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8640965
• 关键词: Congenital Abnormality; Developmental Biology; System; Training

DESCRIPTION (provided by applicant): Systems biology is a relatively new discipline used to understand the complex interactions underlying healthy and diseased states of a cell, tissue, or organism, requiring knowledge of networks of processes and molecular and protein interactions within and among cells, organs, and an organism as a whole. Studies of normal development and birth defects are more established classical disciplines. However to date, there has been very little integration of system biologic approaches to the study of development and inborn errors of development. Scientists who are versed in both mathematics and biology are needed to address the complexities of development biology by examining the thousands to millions of factors and events that occur simultaneously in a temporospatial and quantitative manner during the lifetime of an organism. Thus, to fill the void of scientists trained in these multiple disciplnes, we propose a new and integrated training program, "Interdisciplinary Training in Systems and Developmental Biology and Birth Defects" at Mount Sinai School of Medicine, which has the commitment and infrastructure to administer a successful and rigorous educational program. The overall organization includes at least 28 faculty from 12 different departments, institutes, and centers as well as 3 multidisciplinary training areas (Developmental and Regenerative Biology, Genetics and Genomics Sciences, and Systems Biology and Disease Therapeutics) and the Graduate School of Biological Sciences. An outstanding group of scientists and educators with expertise in systems biology, developmental biology or birth defects, will be the Director, co-Directors, and the members of the External Advisory Committee, Executive Faculty Committee, and the Curriculum Committee, who will provide the leadership and administration for the program. The Curriculum will emphasize the integration of concepts of developmental biology, inborn errors of development, genomics, molecular biology, biochemistry, physiology, pharmacology; and quantitative reasoning, computational biology, and bioinformatics. In addition, new course modules, journal clubs, and seminar series integrating systems biology, developmental biology and birth defects will be created to enhance the unique learning experience. The infrastructure of the training program evaluation; selection of potential candidates; institutional environment, commitment and resources; recruitment and retention; plan to enhance diversity; and training in responsible conduct of research are already existent for other NIH-funded training programs at Mount Sinai and can be applied to this new program. The program, which will be set within a tightly knit medical school and hospital environment, provides exciting and unique opportunities for study from genomes and proteins to cells to animal models to humans at the bench and the bedside. This proposed training will undoubtedly produce future scientists ready for the new frontier of systems and developmental biology.

描述（由申请人提供）：系统生物学是一门相对较新的学科，用于了解细胞，组织或生物体健康和患病状态的复杂相互作用，需要了解过程中和分子和蛋白质相互作用的知识，并且在细胞，器官之间，器官之间以及整个生物体。正常发育和先天缺陷的研究是更确定的经典学科。但是，迄今为止，系统生物学方法的整合很少，用于研究发展和天生的发展错误。需要精通数学和生物学的科学家，以通过在生物体的一生中以暂时的和定量的方式研究数以千计的因素和事件来解决发展生物学的复杂性。因此，为了填补在这些多个学科中培训的科学家的空白，我们提出了一项新的综合培训计划，即西奈山医学院的“系统，发展生物学和出生缺陷的跨学科培训”，该计划具有成功和严格的教育计划，该计划具有承诺和基础设施。整个组织包括来自12个不同部门，研究所和中心的至少28个教职员工，以及3个多学科培训领域（发展和再生生物学，遗传学和基因组学科学以及系统生物学和疾病治疗学）和生物学科学研究生院。具有系统生物学，发展生物学或先天缺陷的专业知识的杰出科学家和教育工作者将是外部咨询委员会，执行学院委员会和课程委员会的董事，联合主任，他们将为该计划提供领导和管理。该课程将强调发育生物学概念，生物发展错误，基因组学，分子生物学，生物化学，生理学，药理学的概念的整合；以及定量推理，计算生物学和生物信息学。此外，还将创建新的课程模块，期刊俱乐部和研讨会系列集成了系统生物学，发育生物学和出生缺陷，以增强独特的学习体验。培训计划评估的基础设施；选择潜在的候选人；制度环境，承诺和资源；招募和保留；计划增强多样性；西奈山的其他NIH资助的培训计划已经存在负责任的研究培训，可以应用于该新计划。该计划将在紧密的医学院和医院环境中设置，为从基因组和蛋白质到细胞再到动物模型再到卧床和床边的人类的研究提供了令人兴奋而独特的机会。拟议的培训无疑将为未来的科学家提供准备，以准备新的系统和发育生物学领域。