Placode patterning by the anterior neural border and the Wnt signalling pathway

前神经边界和 Wnt 信号通路的基板图案

• 批准号: G0600198/1
• 负责人: Corinne Houart
• 金额: $ 51.56万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0600198%2F1
• 关键词: Placode; patterning; anterior; neural; border

This project aims to identify the key molecules controlling the formation of the nose and adenohypophysis. These organs develop from adjacent discrete ectodermal thickenings called cranial placodes. These placodes are therefore essential for the development of both sensory and neuro-endocrine systems. We have identified a specific cell population located in the very early central nervous system that is crucial for development of the telencephalon (forming the cortex in human). This special signalling cell population also lies adjacent to the precursors of both nose and adeno-hypophysis. We will explore the role of the signalling cell population (and its known secreted molecules) in controlling the development of these placodes. The cellular and molecular mechanisms leading to the establishment of both the nose and the hypophysis are not yet understood and this study will bring some novel understanding of these processes. It will also participate to the understanding of human genetic abnormalities affecting the development of olfaction, and hormonal dysfunction due to failure in hypophyseal development.

该项目旨在确定控制鼻子和腺垂体形成的关键分子。这些器官由邻近的离散外胚层增厚发育而来，这种外胚层增厚称为头盖骨。因此，这些安慰剂对感觉系统和神经内分泌系统的发育都是必不可少的。我们已经确定了位于非常早期的中枢神经系统中的特定细胞群，这对端脑(形成人类的皮质)的发育至关重要。这种特殊的信号细胞群也位于鼻部和腺垂体的前体附近。我们将探索信号细胞群(及其已知的分泌分子)在控制这些安慰剂的发育中的作用。导致鼻部和脑垂体建立的细胞和分子机制目前还不清楚，这项研究将带来对这些过程的一些新的理解。它还将参与了解影响嗅觉发育的人类遗传异常，以及由于垂体发育失败而导致的荷尔蒙功能障碍。