Placode patterning by the anterior neural border and the Wnt signalling pathway
前神经边界和 Wnt 信号通路的基板图案
基本信息
- 批准号:G0600198/1
- 负责人:
- 金额:$ 51.56万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2007
- 资助国家:英国
- 起止时间:2007 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This project aims to identify the key molecules controlling the formation of the nose and adenohypophysis. These organs develop from adjacent discrete ectodermal thickenings called cranial placodes. These placodes are therefore essential for the development of both sensory and neuro-endocrine systems. We have identified a specific cell population located in the very early central nervous system that is crucial for development of the telencephalon (forming the cortex in human). This special signalling cell population also lies adjacent to the precursors of both nose and adeno-hypophysis. We will explore the role of the signalling cell population (and its known secreted molecules) in controlling the development of these placodes. The cellular and molecular mechanisms leading to the establishment of both the nose and the hypophysis are not yet understood and this study will bring some novel understanding of these processes. It will also participate to the understanding of human genetic abnormalities affecting the development of olfaction, and hormonal dysfunction due to failure in hypophyseal development.
该项目旨在确定控制鼻和腺垂体形成的关键分子。这些器官是从相邻的离散外胚层增厚称为颅基板。因此,这些基板对于感觉系统和神经内分泌系统的发育至关重要。我们已经确定了一个特定的细胞群位于非常早期的中枢神经系统,这是至关重要的端脑(形成大脑皮层在人类)的发展。这种特殊的信号细胞群也位于鼻和腺垂体的前体附近。我们将探讨信号细胞群(及其已知的分泌分子)在控制这些基板的发展中的作用。导致鼻和垂体建立的细胞和分子机制尚不清楚,这项研究将为这些过程带来一些新的理解。它还将参与对影响嗅觉发展的人类遗传异常的理解,以及由于垂体发育失败而导致的激素功能障碍。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Corinne Houart其他文献
13-P042 Dkk1 regulates patterning and neurogenesis of the zebrafish eye
- DOI:
10.1016/j.mod.2009.06.515 - 发表时间:
2009-08-01 - 期刊:
- 影响因子:
- 作者:
Joao Peres;Corinne Houart - 通讯作者:
Corinne Houart
A small population of anterior cells patterns the forebrain during zebrafish gastrulation
一小群前体细胞在斑马鱼原肠胚形成过程中对前脑进行模式化。
- DOI:
10.1038/35853 - 发表时间:
1998-02-19 - 期刊:
- 影响因子:48.500
- 作者:
Corinne Houart;Monte Westerfield;Stephen W. Wilson - 通讯作者:
Stephen W. Wilson
Dopaminergic neuronal cluster size is determined during early forebrain patterning
多巴胺能神经元簇的大小是在早期前脑模式形成过程中确定的
- DOI:
10.1242/dev.024232 - 发表时间:
2008 - 期刊:
- 影响因子:1.8
- 作者:
N. Russek‐Blum;A. Gutnick;H. Nabel;J. Blechman;Nicole Staudt;R. Dorsky;Corinne Houart;G. Levkowitz - 通讯作者:
G. Levkowitz
The pineal complex/epiphysis is a placode, strictly specified by the combinatorial activity of the transcription factors Flh/Noto and Dlx3
- DOI:
10.1016/j.ydbio.2008.05.491 - 发表时间:
2008-07-15 - 期刊:
- 影响因子:
- 作者:
Corinne Houart;James Hutt;Isabelle Foucher;Corinne Houart - 通讯作者:
Corinne Houart
Corinne Houart的其他文献
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{{ truncateString('Corinne Houart', 18)}}的其他基金
Using fish biodiversity to understand brain evolution
利用鱼类生物多样性来了解大脑进化
- 批准号:
BB/V018175/1 - 财政年份:2022
- 资助金额:
$ 51.56万 - 项目类别:
Research Grant
Integration of cell-cell interactions and cell division by novel Dkk1 functions
通过新颖的 Dkk1 功能整合细胞间相互作用和细胞分裂
- 批准号:
BB/V015362/1 - 财政年份:2021
- 资助金额:
$ 51.56万 - 项目类别:
Research Grant
Automated high throughput high-resolution imaging
自动化高通量高分辨率成像
- 批准号:
BB/V019481/1 - 财政年份:2021
- 资助金额:
$ 51.56万 - 项目类别:
Research Grant
Post-transcriptional regulation in motor and cognitive disorders
运动和认知障碍的转录后调节
- 批准号:
MR/T033126/1 - 财政年份:2020
- 资助金额:
$ 51.56万 - 项目类别:
Research Grant
Evolutionary mechanisms controlling brain size and complexity
控制大脑大小和复杂性的进化机制
- 批准号:
BB/S001530/1 - 财政年份:2018
- 资助金额:
$ 51.56万 - 项目类别:
Research Grant
Novel Function of Splicing factors in Establishment and Maintenance of Neuronal Connectivity
剪接因子在神经元连接建立和维持中的新功能
- 批准号:
BB/P001599/1 - 财政年份:2017
- 资助金额:
$ 51.56万 - 项目类别:
Research Grant
Control of Cell-Cell interactions in Forebrain Morphogenesis.
前脑形态发生中细胞间相互作用的控制。
- 批准号:
BB/L022303/1 - 财政年份:2014
- 资助金额:
$ 51.56万 - 项目类别:
Research Grant
Forebrain development: From neural plate to cortical specification
前脑发育:从神经板到皮质规范
- 批准号:
G0901525/1 - 财政年份:2010
- 资助金额:
$ 51.56万 - 项目类别:
Research Grant
Specification of forebrain territories: commitments and signalling.
前脑区域的规范:承诺和信号。
- 批准号:
BB/E005403/1 - 财政年份:2006
- 资助金额:
$ 51.56万 - 项目类别:
Research Grant
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