Specification of forebrain territories: commitments and signalling.

前脑区域的规范:承诺和信号。

基本信息

  • 批准号:
    BB/E005403/1
  • 负责人:
  • 金额:
    $ 52.68万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2006
  • 资助国家:
    英国
  • 起止时间:
    2006 至 无数据
  • 项目状态:
    已结题

项目摘要

In all vertebrates, from fish to humans, the brain is formed of three main regions, the forebrain, midbrain and hindbrain. The forebrain gives rise to our cortex, in which our conscious thoughts, emotions and many of our memories reside. It also forms the eyes and the diencephalon. How the forebrain region becomes sub-divided into telencephalon (future cortex), eye and diencephalon remains a mystery. Our aim is to understand the mechanisms underlying this subdivision. A significant number of early brain malformations observed in human foetuses (for instance following viral infection in early stage of pregnancy, or more rarely indeed by genetic defects) are due to mistakes in the steps required for normal forebrain partition. Knowing the mechanisms required for normal forebrain development will therefore help understanding the cause of these human malformations. The brain comes from a simple sheet of tissue, called neural plate. This plate closes into a tube from which the most rostral end develops into the forebrain. We already discovered that some of the decisions required to divide the forebrain into specific areas are taken before the formation of the neural tube, inside the rostral neural plate. We showed that the anterior neural border (the most rostral end of the neural plate, ANB) is required for formation of the telencephalon and is a source of signalling that needs to be received by the rostral plate in order for these cells to become telencephalon and subsequently form a cortex. We also gathered preliminary results suggesting that other irreversible decisions are taken in the neural plate. These decisions are establishing the precursors for specialised areas of the diencephalon. In this proposal, we aim to identify the neural plate cell populations that are the earliest to commit to a defined diencephalic identity and to test whether these cells are sending signals potentially able to orchestrate the identities of the areas surrounding them. We will also get a profile of the different genes that are specifically expressed in each of the studied neural plate areas, in order to get insight into the molecular nature of their differences. By the end of the three years of research, we will have identified the earliest commitments leading to specific diencephalic areas and anticipate identifying some of the molecular players underlying the establishment of the diencephalic subdivisions. We also hope to identify a novel signalling centre responsible for some of the early organisation of the forebrain territory.
在所有脊椎动物中,从鱼类到人类,大脑由三个主要区域组成,前脑,中脑和后脑。前脑产生了我们的皮层,我们有意识的思想,情感和许多记忆都存在于皮层中。它还形成了眼睛和间脑。前脑区域如何被细分为端脑(未来的皮层),眼睛和间脑仍然是一个谜。我们的目的是了解这种细分的机制。在人类胎儿中观察到的大量早期脑畸形(例如在妊娠早期病毒感染后,或更罕见的遗传缺陷)是由于正常前脑分区所需步骤的错误。因此,了解正常前脑发育所需的机制将有助于理解这些人类畸形的原因。大脑来自一片简单的组织,称为神经板。这个板关闭成一个管,从最吻端发育成前脑。我们已经发现,将前脑划分为特定区域所需的一些决定是在吻侧神经板内的神经管形成之前做出的。我们发现,前神经边界(神经板的最前端,ANB)是端脑形成所必需的,并且是需要由喙板接收的信号源,以便这些细胞成为端脑并随后形成皮质。我们还收集了初步结果,表明其他不可逆的决定是在神经板中做出的。这些决定正在为间脑的专门区域建立先驱。在这项提案中,我们的目标是确定最早承诺一个明确的间脑身份的神经板细胞群,并测试这些细胞是否正在发送信号,可能能够协调它们周围区域的身份。我们还将获得在每个研究的神经板区域中特异性表达的不同基因的概况,以便深入了解它们差异的分子性质。在三年的研究结束时,我们将确定导致特定间脑区域的最早承诺,并预计确定间脑亚部建立的一些分子参与者。我们还希望找到一个负责前脑区域一些早期组织的新型信号中心。

项目成果

期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The prethalamus is established during gastrulation and influences diencephalic regionalization.
  • DOI:
    10.1371/journal.pbio.0050069
  • 发表时间:
    2007-04
  • 期刊:
  • 影响因子:
    9.8
  • 作者:
    Staudt N;Houart C
  • 通讯作者:
    Houart C
Pineal progenitors originate from a non-neural territory limited by FGF signalling.
松果体祖细胞起源于受 FGF 信号传导限制的非神经区域。
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Corinne Houart其他文献

13-P042 Dkk1 regulates patterning and neurogenesis of the zebrafish eye
  • DOI:
    10.1016/j.mod.2009.06.515
  • 发表时间:
    2009-08-01
  • 期刊:
  • 影响因子:
  • 作者:
    Joao Peres;Corinne Houart
  • 通讯作者:
    Corinne Houart
A small population of anterior cells patterns the forebrain during zebrafish gastrulation
一小群前体细胞在斑马鱼原肠胚形成过程中对前脑进行模式化。
  • DOI:
    10.1038/35853
  • 发表时间:
    1998-02-19
  • 期刊:
  • 影响因子:
    48.500
  • 作者:
    Corinne Houart;Monte Westerfield;Stephen W. Wilson
  • 通讯作者:
    Stephen W. Wilson
Dopaminergic neuronal cluster size is determined during early forebrain patterning
多巴胺能神经元簇的大小是在早期前脑模式形成过程中确定的
  • DOI:
    10.1242/dev.024232
  • 发表时间:
    2008
  • 期刊:
  • 影响因子:
    1.8
  • 作者:
    N. Russek‐Blum;A. Gutnick;H. Nabel;J. Blechman;Nicole Staudt;R. Dorsky;Corinne Houart;G. Levkowitz
  • 通讯作者:
    G. Levkowitz
The pineal complex/epiphysis is a placode, strictly specified by the combinatorial activity of the transcription factors Flh/Noto and Dlx3
  • DOI:
    10.1016/j.ydbio.2008.05.491
  • 发表时间:
    2008-07-15
  • 期刊:
  • 影响因子:
  • 作者:
    Corinne Houart;James Hutt;Isabelle Foucher;Corinne Houart
  • 通讯作者:
    Corinne Houart

Corinne Houart的其他文献

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{{ truncateString('Corinne Houart', 18)}}的其他基金

Using fish biodiversity to understand brain evolution
利用鱼类生物多样性来了解大脑进化
  • 批准号:
    BB/V018175/1
  • 财政年份:
    2022
  • 资助金额:
    $ 52.68万
  • 项目类别:
    Research Grant
Integration of cell-cell interactions and cell division by novel Dkk1 functions
通过新颖的 Dkk1 功能整合细胞间相互作用和细胞分裂
  • 批准号:
    BB/V015362/1
  • 财政年份:
    2021
  • 资助金额:
    $ 52.68万
  • 项目类别:
    Research Grant
Automated high throughput high-resolution imaging
自动化高通量高分辨率成像
  • 批准号:
    BB/V019481/1
  • 财政年份:
    2021
  • 资助金额:
    $ 52.68万
  • 项目类别:
    Research Grant
Post-transcriptional regulation in motor and cognitive disorders
运动和认知障碍的转录后调节
  • 批准号:
    MR/T033126/1
  • 财政年份:
    2020
  • 资助金额:
    $ 52.68万
  • 项目类别:
    Research Grant
Evolutionary mechanisms controlling brain size and complexity
控制大脑大小和复杂性的进化机制
  • 批准号:
    BB/S001530/1
  • 财政年份:
    2018
  • 资助金额:
    $ 52.68万
  • 项目类别:
    Research Grant
Novel Function of Splicing factors in Establishment and Maintenance of Neuronal Connectivity
剪接因子在神经元连接建立和维持中的新功能
  • 批准号:
    BB/P001599/1
  • 财政年份:
    2017
  • 资助金额:
    $ 52.68万
  • 项目类别:
    Research Grant
Control of Cell-Cell interactions in Forebrain Morphogenesis.
前脑形态发生中细胞间相互作用的控制。
  • 批准号:
    BB/L022303/1
  • 财政年份:
    2014
  • 资助金额:
    $ 52.68万
  • 项目类别:
    Research Grant
Forebrain development: From neural plate to cortical specification
前脑发育:从神经板到皮质规范
  • 批准号:
    G0901525/1
  • 财政年份:
    2010
  • 资助金额:
    $ 52.68万
  • 项目类别:
    Research Grant
Placode patterning by the anterior neural border and the Wnt signalling pathway
前神经边界和 Wnt 信号通路的基板图案
  • 批准号:
    G0600198/1
  • 财政年份:
    2007
  • 资助金额:
    $ 52.68万
  • 项目类别:
    Research Grant

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