Bioinformatics and Biostatistics

生物信息学和生物统计学核心（BBC）将为生物统计学和生物信息学提供支持。 整个PNWRCE。核心将与PNWRCE研究者密切合作，协助研究设计， 在整个“实验生命周期”中进行分析。生物统计学支持包括把握度和样本量 计算，统计分析，以及数据解释和手稿准备的援助。 生物信息学支持包括功能基因组数据分析和整合，网络重建和 预测，以及数学建模和模拟。核心有来自OHSU的联合领导， 提供跨学科和跨机构的专门知识。此外，英国广播公司将提供教育 培训以及职业发展和试点项目咨询。最后，为了留下 随着技术的变化，BBC将提供尖端的方法论和 算法开发由于没有现有的核心或资源具有独特的组合， 技术专长、领域知识和与PNWRCE调查人员的合作历史， 英国广播公司的成立是有充分理由的，并将为RCE提供具有成本效益和有效的支持。

The Bioinformatics & Biostatistics Core (BBC) will provide biostatistics and bioinformatics support to the entire PNWRCE. The Core will work closely with the PNWRCE investigators to assist with study design and analysis throughout the "experimental life cycle". Biostatistical support includes power and sample size calculations, statistical analysis, as well as assistance with data interpretation and manuscript preparation. Bioinformatics support includes functional genomic data analysis and integration, network reconstruction and predictions, as well as mathematical modeling and simulation. The Core has joint leadership from OHSU and PNNL providing inter-disciplinary and inter-institutional expertise. In addition, the BBC will provide education and training, as well as consultations for career development and pilot projects. Finally, in order to stay responsive and dynamic to changes in technology, the BBC will provide cutting-edge methodological and algorithm development. As there is no existing core or resource which has the unique combination of technical expertise, domain knowledge and collaborative history with the PNWRCE investigators, the creation of the BBC is well justified and will allow cost-effective and efficient support for the RCE.