Biostatistics and Bioinformatics Core

生物统计学和生物信息学核心

• 批准号: 10629170
• 负责人: Shannon K. McWeeney
• 金额: $ 15.12万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10629170
• 关键词: Bioinformatics; Biological; Biology; Biometry; Collaborations; Complex; Computing Methodologies; Cytomegalovirus; Data; Development; Ensure; Event; FAIR principles; Generations; Genomics; Goals; Hematopoietic stem cells; Human; Infrastructure; Intervention; Knowledge Extraction; Life Cycle Stages; Methodology; Methods; MicroRNAs; Modeling; Molecular; Molecular Profiling; Pathology; Pathway interactions; Phase; Play; Protocols documentation; Regulation; Reproducibility; Research Design; Research Project Grants; Role; Secure; Security; Signal Pathway; Signal Transduction; Standardization; System; Technology; Technology Assessment; Viral; Virus; Visualization; Visualization software; Work; candidate validation; catalyst; cost effective; data management; data standards; experimental study; insight; mathematical model; method development; multiple omics; novel; outreach; phenotypic data; predictive modeling; programs; reactivation from latency; virus virus interaction

SUMMARY - BIOSTATISTICS AND BIOINFORMATICS CORE (CORE B) The Biostatistics and Bioinformatics Core (Core B) serves as the translational catalyst for the PPG by integrating the diverse ‘omics’ data readouts to develop systems-level mathematical models to help advance the molecular understanding of HCMV latency and reactivation. Core B works in close collaboration with the PPG research projects and the other cores to provide pre-processing, analysis, modeling and computational support as well as development of timely new methods through cutting-edge computational methods development; outreach support; and assistance with dissemination. To achieve the full potential of the PPG center, it is essential that data be accessible—in terms of both security (i.e., having secure, ready access) and interpretability (i.e., is high quality, contextual and information rich). Core B serves as the data steward for the PPG. The goal of Core B is to support all aspects of the data life cycle starting at data generation. The Core B team will build upon its extensive data management, data standardization, biostatistical, multi-omics, and bioinformatics expertise to ensure reproducible, transparent workflows and protocols that maximize knowledge extraction.

摘要 - 生物统计学和生物信息学核心（核心B） 生物统计学和生物信息学核心（核心B）通过集成来作为PPG的转化催化剂 潜水员“幻象”数据读数以开发系统级数学模型，以帮助推进分子 了解HCMV潜伏期和重新激活。核心B与PPG研究密切合作 项目和其他核心也提供预处理，分析，建模和计算支持 作为通过尖端计算方法开发开发及时的新方法；外展 支持;并协助传播。为了实现PPG中心的全部潜力，至关重要的是 可访问数据 - 在安全性（即具有安全，现成的访问）和可解释性（即高度）方面 质量，上下文和信息丰富）。核心B充当PPG的数据管家。核心B的目标是 支持从数据生成开始的数据生命周期的所有方面。核心B团队将在其基础上建立 广泛的数据管理，数据标准化，生物统计学，多媒体和生物信息学专业知识 确保可重现，透明的工作流程和协议，以最大程度地提取知识提取。