Bioinformatics and Biostatistics

生物信息学和生物统计学

• 批准号: 8376412
• 负责人: Shannon K. McWeeney
• 金额: $ 42.02万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-01 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8376412
• 关键词: Address; Algorithms; Animal Model; Behavior; Bioinformatics; Biological; Biometry; Biostatistics Core; Communities; Computational Biology; Computer Simulation; Consultations; Data; Data Analyses; Development; Emerging Technologies; Ensure; Experimental Designs; Immunology; Joints; Knowledge; Leadership; Life Cycle Stages; Manuscripts; Methodology; Methods; Pacific Northwest; Pilot Projects; Preparation; Public Health; Recording of previous events; Research Design; Research Personnel; Research Project Grants; Resources; Sample Size; System; Systems Biology; Technical Expertise; Technology; Training; Training Programs; Training and Education; Virulence; Work; career development; comparative; cost effective; data integration; design; functional genomics; mathematical model; network models; reconstruction; research study; therapeutic target; tool

The Bioinformatics & Biostatistics Core (BBC) will provide biostatistics and bioinformatics support to the entire PNWRCE. The Core will work closely with the PNWRCE investigators to assist with study design and analysis throughout the "experimental life cycle". Biostatistical support includes power and sample size calculations, statistical analysis, as well as assistance with data interpretation and manuscript preparation. Bioinformatics support includes functional genomic data analysis and integration, network reconstruction and predictions, as well as mathematical modeling and simulation. The Core has joint leadership from OHSU and PNNL providing inter-disciplinary and inter-institutional expertise. In addition, the BBC will provide education and training, as well as consultations for career development and pilot projects. Finally, in order to stay responsive and dynamic to changes in technology, the BBC will provide cutting-edge methodological and algorithm development. As there is no existing core or resource which has the unique combination of technical expertise, domain knowledge and collaborative history with the PNWRCE investigators, the creation of the BBC is well justified and will allow cost-effective and efficient support for the RCE.

生物信息学与生物统计学核心（BBC）将为生物统计学和生物信息学提供支持 整个pnwrce。核心将与PNWRCE调查人员紧密合作，以协助研究设计和 在整个“实验生命周期”中分析。生物统计支持包括功率和样本量 计算，统计分析以及有关数据解释和手稿准备的帮助。 生物信息学支持包括功能基因组数据分析和集成，网络重建和 预测以及数学建模和仿真。核心具有OHSU的联合领导和 PNNL提供跨学科和机构间专业知识。此外，英国广播公司还将提供教育 和培训，以及职业发展和试点项目的咨询。最后，为了留下 对技术变化的响应敏感和动态，英国广播公司将提供尖端的方法论和 算法开发。由于没有现有的核心或资源，它具有独特的组合 技术专长，领域知识和合作历史与PNWRCE调查人员， BBC的创建是有道理的，将为RCE提供具有成本效益和有效的支持。