Bioinformatics and Biostatistics

生物信息学和生物统计学

• 批准号: 8234058
• 负责人: Shannon K. McWeeney
• 金额: $ 34.47万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8234058
• 关键词: Address; Algorithms; Animal Model; Behavior; Bioinformatics; Biological; Biometry; Biostatistics Core; Communities; Computational Biology; Computer Simulation; Consultations; Data; Data Analyses; Development; Emerging Technologies; Ensure; Experimental Designs; Immunology; Joints; Knowledge; Leadership; Life Cycle Stages; Manuscripts; Methodology; Methods; Pacific Northwest; Pilot Projects; Preparation; Public Health; Recording of previous events; Research Design; Research Personnel; Research Project Grants; Resources; Sample Size; System; Systems Biology; Technical Expertise; Technology; Training; Training Programs; Training and Education; Virulence; Work; career development; comparative; cost effective; data integration; design; functional genomics; mathematical model; network models; reconstruction; research study; therapeutic target; tool

The Bioinformatics & Biostatistics Core (BBC) will provide biostatistics and bioinformatics support to the entire PNWRCE. The Core will work closely with the PNWRCE investigators to assist with study design and analysis throughout the "experimental life cycle". Biostatistical support includes power and sample size calculations, statistical analysis, as well as assistance with data interpretation and manuscript preparation. Bioinformatics support includes functional genomic data analysis and integration, network reconstruction and predictions, as well as mathematical modeling and simulation. The Core has joint leadership from OHSU and PNNL providing inter-disciplinary and inter-institutional expertise. In addition, the BBC will provide education and training, as well as consultations for career development and pilot projects. Finally, in order to stay responsive and dynamic to changes in technology, the BBC will provide cutting-edge methodological and algorithm development. As there is no existing core or resource which has the unique combination of technical expertise, domain knowledge and collaborative history with the PNWRCE investigators, the creation of the BBC is well justified and will allow cost-effective and efficient support for the RCE.

生物信息学和生物统计核心(BBC)将为 整个PNWRCE。CORE将与PNWRCE调查人员密切合作，协助研究设计和 在整个“实验生命周期”中进行分析。生物统计学支持包括能力和样本量 计算、统计分析以及协助数据解释和手稿准备。 生物信息学支持包括功能基因组数据分析和整合、网络重建和 预测，以及数学建模和模拟。核心由OHSU和OHSU联合领导 PNNL提供跨学科和跨机构的专门知识。此外，英国广播公司将提供教育 并为职业发展和试点项目提供咨询。最后，为了留下来 对技术变化的反应和动态，BBC将提供尖端的方法和 算法开发。因为不存在具有以下唯一组合的现有核心或资源 与PNWRCE调查人员的技术专长、领域知识和合作历史 创建英国广播公司是有充分理由的，并将为区域经济共同体提供具有成本效益和效率的支持。