Pacific NorthWest Regional Center of Excellence (PNWRCE)

西北太平洋区域卓越中心 (PNWRCE)

• 批准号: 7633622
• 负责人: JAY A NELSON
• 金额: $ 836.87万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-20 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7633622
• 关键词: Pacific; NorthWest; Regional; Center; Excellence

DESCRIPTION (provided by applicant): The goal of this application is to establish the Pacific Northwest Regional Center of Excellence (PNWRCE) in NIAID Region X. The two inter-related but distinct PNWRCE themes that we have selected reflect not only the scientific strengths at our institutions but also the unmet needs that we perceive are absent in the NIAID biodefense and emerging disease program. The first theme "Identification of Age-Related Defects in the Immune System to Develop Vaccines and Supplemental Therapies" will include two projects. The overall goal of these projects is to develop new vaccines and immune supplemental therapies for immune vulnerable populations such as aged individuals. The first project a P01 will investigate the hypothesis that certain unifying manipulations can be performed to increase T cell immunity in immune vulnerable populations to a broad group of pathogens. The second project will develop a novel and effective vaccine platform for safely immunizing both healthy and vulnerable populations against YFV. The second theme will center on "The use of systems biology, functional genomics and genetics to characterize pathogen-host response for biodefense and emerging disease organisms." This theme will include four projects with the overall goal of using systems approaches to identify new targets and therapeutics for Category A-C agents. The goal of the first project a P01 is to use systems approaches to identify common host susceptibility alleles and signaling circuitry that enhance highly pathogenic pneumonic viruses and Ebola virus replication and pathogenesis and to identify key cellular targets and immune correlates that influence severe disease outcomes. The goal of the second project a P01 is focused on defining innate immune mechanisms, therapeutic targets, and antiviral compounds that limit flavivirus infection and pathogenesis. The third project an R01 will use systems approaches to characterize Francisella mutants that exhibit either altered intracellular growth rates or induce cellular apoptosis. The last project an RO1 will use a combination of genetic, biochemical, and computational approaches to elucidate B. pseudomallei host pathogen response during both the septicemic as well as the intracellular phases of the disease. STRATEGIC MANAGEMENT PLAN/CORE A: Strategic Plan and Management (Project SMP Leader, J. Nelson) STRATEGIC MANAGEMENT PLAN/CORE A DESCRIPTION (provided by applicant): The PNWRCE is a Regional Center of Excellence (RCE) that includes the majority of the institutions in the Northwest including Oregon Health and Science University (OHSU), the University of Washington (UW), Pacific Northwest National Laboratory (PNNL), and the University of Idaho (Ul) as well as institutions outside our region such as the University of Arizona (UA), University of Wisconsin, the University of North Carolina at Chapel Hill, Washington University in St. Louis, the Memorial Sloan-Kettering Cancer Center in New York, and the Rocky Mountain Laboratories (NIAID) in Hamilton, Montana. The Center has a strong multidisciplinary character, exemplified by highly interactive Research Projects and associated Scientific Cores as well as Developmental Projects, Training Programs, and an Emergency Preparedness Program. A strong administrative and organizational structure is vital to the Center's ability to successfully carry out each of the functions of the center to promote synergy between programmatic elements. In this Core, we outline in detail our administrative structure, the role of the Director, Co-Director, Administrator, and Advisory Boards in managing Center activities. Clearly, the success of the Administrative Core is dependent upon its personnel, and we have assembled an experienced team of Directors and Administrators. We are also fortunate to have a Steering Committee and participants that are composed of highly regarded experts in the fields of virology, bacteriology and immunology, as well as proteomics and bioinformatics to provide guidance, selection of projects and career development awards to maintain the function, productivity, flexibility and excellence of the center. The Specific Aims of the Administrative Core are to: 1) Provide an organizational and programmatic structure to promote scientific interactions, research productivity, and training. 2) Provide oversight, planning, priority setting, and decision-making processes. 3) Ensure that the Center is compliant with IRB and IACUC issues. In addition the Administrative Core is tasked with ensuring that the Center continues to meet all criteria described in the NIAID Research Centers of Excellence in Biodefense and Emerging Disease Program and Review Guidelines, including a data sharing plan, state-of-the-art facilities, innovation, multidisciplinary involvement, thematic integration, and synergy among RCEs.

描述（由申请人提供）：本申请的目标是在 NIAID X 区建立太平洋西北地区卓越中心 (PNWRCE)。我们选择的两个相互关联但截然不同的 PNWRCE 主题不仅反映了我们机构的科学优势，而且反映了我们认为 NIAID 生物防御和新发疾病计划中缺乏的未满足的需求。第一个主题“识别免疫系统中与年龄相关的缺陷以开发疫苗和补充疗法”将包括两个项目。这些项目的总体目标是为老年人等免疫弱势群体开发新的疫苗和免疫补充疗法。第一个项目 P01 将研究这样一个假设：可以进行某些统一操作来增强免疫脆弱人群对广泛病原体的 T 细胞免疫力。第二个项目将开发一种新颖有效的疫苗平台，用于为健康和弱势群体安全地免疫黄热病病毒。第二个主题将集中在“利用系统生物学、功能基因组学和遗传学来表征生物防御和新出现的疾病生物体的病原体-宿主反应”。该主题将包括四个项目，总体目标是使用系统方法来确定 A-C 类药物的新靶点和治疗方法。第一个 P01 项目的目标是使用系统方法来识别常见的宿主易感性等位基因和信号电路，以增强高致病性肺炎病毒和埃博拉病毒的复制和发病机制，并识别影响严重疾病结果的关键细胞靶点和免疫相关因素。第二个项目 a P01 的目标侧重于定义先天免疫机制、治疗靶点以及限制黄病毒感染和发病机制的抗病毒化合物。第三个项目 R01 将使用系统方法来表征弗朗西斯菌突变体，这些突变体表现出改变的细胞内生长速率或诱导细胞凋亡。最后一个项目 RO1 将结合遗传、生化和计算方法来阐明类鼻疽伯克氏菌宿主病原体在败血症和细胞内阶段的反应。 战略管理计划/核心 A：战略计划和管理（SMP 项目负责人 J. Nelson） 战略管理计划/核心描述（由申请人提供）：PNWRCE 是一个区域卓越中心 (RCE)，包括西北地区的大多数机构，包括俄勒冈健康与科学大学 (OHSU)、华盛顿大学 (UW)、太平洋西北国家实验室 (PNNL) 和爱达荷大学 (Ul) 以及我们地区以外的机构，例如亚利桑那大学 (UA)、 威斯康星大学、北卡罗来纳大学教堂山分校、圣路易斯华盛顿大学、纽约纪念斯隆-凯特琳癌症中心和蒙大拿州汉密尔顿落基山实验室 (NIAID)。该中心具有很强的多学科特征，例如高度互动的研究项目和相关的科学核心以及发展项目、培训计划和应急准备计划。强大的行政和组织结构对于中心成功履行中心各项职能、促进计划要素之间协同作用的能力至关重要。在本核心中，我们详细概述了我们的管理结构、主任、联合主任、管理员和顾问委员会在管理中心活动中的作用。显然，行政核心的成功取决于其人员，我们组建了一支经验丰富的董事和行政人员团队。我们还幸运地拥有一个由病毒学、细菌学和免疫学以及蛋白质组学和生物信息学领域备受推崇的专家组成的指导委员会和参与者，提供指导、项目选择和职业发展奖项，以维持中心的功能、生产力、灵活性和卓越性。行政核心的具体目标是： 1) 提供组织和计划结构，以促进科学互动、研究生产力和培训。 2) 提供监督、规划、优先级设定和决策流程。 3) 确保中心符合 IRB 和 IACUC 问题。此外，行政核心的任务是确保该中心继续满足 NIAID 生物防御和新发疾病卓越研究中心计划和审查指南中描述的所有标准，包括数据共享计划、最先进的设施、创新、多学科参与、主题整合以及 RCE 之间的协同作用。