Administrative Core

核心C项目总结 这个PPG的总体目标是阐明hcmv调节细胞信号的分子机制。 在建立和维持病毒潜伏期和病毒重新激活，以及如何病毒失调 HSC信号的缺失可能会影响造血功能。为了实现这一目标，我们组建了一个非凡的 病毒学家小组将在五个高度互动的项目和两个科学核心方面进行合作。该计划 行政核心主任(PD)和首席调查员是Jay Nelson博士，他是一名大四学生 分子病毒学家，具有研究巨细胞病毒和 它们的宿主环境。纳尔逊博士将与安德鲁·尤罗奇科博士共同领导这一项目，后者是一名 研究人类巨细胞病毒传播和发病机制的国际专家。他们将会是 由一支出色的管理团队提供协助，该团队在管理和管理方面拥有良好的记录 大型、复杂的赠款和合同，如#年太平洋西北地区英才中心 生物防御和新发传染病(PNWRCE)和NIAID佐剂发现合同。这个 本小组在组织、报告和沟通方面的丰富经验 多机构研究项目的成功管理将是确保成功的 这个PPG的管理。行政核心将作为行政、沟通和 对整个项目进行监控。该核心将为所有项目和所有科学核心服务，并将与 所有参与这项计划的机构。行政核心还将作为中心互动点 美国国立卫生研究院的项目。最后，行政团队将协助项目主管确保定期和 该联盟成员之间的及时沟通以及向NIAID计划的报告。

CORE C PROJECT SUMMARY The overall goal of this PPG is to elucidate the molecular mechanisms of HCMV regulation of cellular signaling in the establishment and maintenance of viral latency and viral reactivation, as well as how viral dysregulation of HSC signaling may compromise hematopoiesis. To meet this goal we have assembled an extraordinary group of virologists who will collaborate in five highly interactive projects and two scientific cores. The Program Director (PD) and Principal Investigator of the Administrative Core is Jay Nelson, Ph.D., who is a senior molecular virologist with extensive experience studying the molecular interaction of cytomegaloviruses and their host environment. Dr. Nelson will be co-leading this program with Dr. Andrew Yurochko, who is an international expert in the study of Human Cytomegalovirus dissemination and pathogenesis. They will be assisted by an exceptional administrative team that has a proven track record in administering and managing large, complex grants and contracts such as the Pacific Northwest Regional Center of Excellence in Biodefense and Emerging Infectious Diseases (PNWRCE) and a NIAID Adjuvant Discovery Contract. The significant experience of this group with the organization, reporting and communications associated with the successful administration of multi-institutional research programs will be invaluable in ensuring a successful management of this PPG. The Administrative Core will serve as a hub for administration, communication and monitoring for the entire program. The core will serve all projects and all scientific cores, and it will interact with all institutions involved in this program. The Administrative Core will also serve as a central point of interaction with NIH Program. Finally, the administrative team will assist the program director in ensuring regular and timely communication among the members of this consortium as well as reporting to NIAID Program.