Administrative Core

核心C项目总结 本PPG的总体目标是阐明HCMV调节细胞信号传导的分子机制 在建立和维持病毒潜伏期和病毒再活化，以及如何病毒失调， HSC信号传导可能会损害造血。为了实现这一目标，我们组织了一个非凡的 一组病毒学家将在五个高度互动的项目和两个科学核心中合作。程序 管理核心的主任（PD）和主要研究者是Jay纳尔逊，Ph.D.，她是一名高年级学生 分子病毒学家，在研究巨细胞病毒的分子相互作用方面具有丰富经验， 他们的宿主环境。纳尔逊博士将与安德鲁·尤罗奇科博士共同领导这一计划，安德鲁·尤罗奇科博士是一名 研究人类巨细胞病毒传播和发病机制的国际专家。他们将 由一个卓越的行政团队协助，该团队在行政和管理方面有着良好的记录 大型，复杂的赠款和合同，如太平洋西北地区卓越中心， 生物防御和新发传染病（PNWRCE）和NIAID佐剂发现合同。的 该小组在组织、报告和沟通方面的丰富经验， 多机构研究计划的成功管理将是确保成功的宝贵 管理这个PPG。行政核心将作为行政、通信和 监控整个项目。核心将服务于所有项目和所有科学核心，它将与 所有参与该计划的机构。行政核心还将作为互动的中心点 NIH计划。最后，行政团队将协助项目主任确保定期和 联合体成员之间的及时沟通以及向NIAID计划报告。

CORE C PROJECT SUMMARY The overall goal of this PPG is to elucidate the molecular mechanisms of HCMV regulation of cellular signaling in the establishment and maintenance of viral latency and viral reactivation, as well as how viral dysregulation of HSC signaling may compromise hematopoiesis. To meet this goal we have assembled an extraordinary group of virologists who will collaborate in five highly interactive projects and two scientific cores. The Program Director (PD) and Principal Investigator of the Administrative Core is Jay Nelson, Ph.D., who is a senior molecular virologist with extensive experience studying the molecular interaction of cytomegaloviruses and their host environment. Dr. Nelson will be co-leading this program with Dr. Andrew Yurochko, who is an international expert in the study of Human Cytomegalovirus dissemination and pathogenesis. They will be assisted by an exceptional administrative team that has a proven track record in administering and managing large, complex grants and contracts such as the Pacific Northwest Regional Center of Excellence in Biodefense and Emerging Infectious Diseases (PNWRCE) and a NIAID Adjuvant Discovery Contract. The significant experience of this group with the organization, reporting and communications associated with the successful administration of multi-institutional research programs will be invaluable in ensuring a successful management of this PPG. The Administrative Core will serve as a hub for administration, communication and monitoring for the entire program. The core will serve all projects and all scientific cores, and it will interact with all institutions involved in this program. The Administrative Core will also serve as a central point of interaction with NIH Program. Finally, the administrative team will assist the program director in ensuring regular and timely communication among the members of this consortium as well as reporting to NIAID Program.