International Herpesvirus Workshop

项目摘要 该提案要求将资金用于支持博士后研究员的差旅费和注册费， 研究生参加在德国柏林举行的第45届国际疱疹病毒研讨会。IHW是 研究所有疱疹病毒的科学家的主要年度会议，并在其第45届会议上建立了良好的基础。 年这次会议非常成功，部分原因是世界各国的热情参与， 疱疹病毒研究的领军人物讲习班的优势在于相互交流， 比较不同的疱疹病毒，对关键问题的不同方法和对支持和 该领域主要研究人员的参与，最重要的是包括有前途的年轻研究人员， 学生在训练。此外，该论坛是真正的国际性论坛，世界各地的与会者基础广泛。的 这次会议的医学重要性清楚地表明，从各种各样的疾病所造成的现在， 识别出八种人类疱疹病毒。这些包括皮肤和眼睛溃疡（HSV-1）、生殖器病变（HSV-2）、皮肤溃疡（HSV-3）和皮肤溃疡（HSV-4）。 2）、脑膜炎和脑炎（HSV-1和HSV-2）、传染性单核细胞增多症（EBV）、水痘和带状疱疹 （VZV）.巨细胞病毒是一个主要的原因出生缺陷，包括智力低下，失明和耳聋，由于 先天性传播也是艾滋病患者和器官移植中的重要机会致病菌 受惠人士此外，CMV已经被认为是在发展中的致病性贡献者。 动脉粥样硬化癌症也与疱疹病毒感染有关。EB病毒与伯基特氏病有关 淋巴瘤、其它B细胞瘤形成和鼻咽癌。最新的人类疱疹病毒 HHV-8或KSHV与艾滋病患者的卡波西肉瘤有关， 免疫抑制的人在其他群体。所有的疱疹病毒都会终生存在， 在免疫受损个体的治疗中存在重大问题。疾病引起的复活 大多数人疱疹病毒是各种免疫患者发病和死亡重要原因 人口。研讨会将对以下主题采取跨学科的方法：病毒结构， 病毒进入和细胞-细胞传播的机制，膜蛋白，发病机制和潜伏期，DNA复制， 疫苗接种和免疫应答，转录调控，基因表达调控，化疗 靶点和病毒基因治疗。

Project Summary This proposal requests funds to be used to support travel and registration fees for postdoctoral fellows and graduate students to attend the 45th International Herpesvirus Workshop (IHW) in Berlin, Germany. The IHW is the major annual meeting for scientists studying all the herpesviruses and is very well established in its 45th year. This meeting has been very successful, in part, because of the enthusiastic participation of the world’s leading herpesvirus researchers. The strength of the Workshop rests on the cross-fertilization that results from comparison of different herpesviruses, different approaches to key questions and on the support and participation of leading researchers in the field, most significantly including promising young investigators and students in training. Moreover, the forum is truly international, with broad-based world-wide attendance. The medical importance of this meeting is clearly indicated from the wide variety of diseases caused by the now- recognized eight human herpesviruses. These include skin and eye ulcerations (HSV-1), genital lesions (HSV- 2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV). CMV is a major cause of birth defects including mental retardation, blindness and deafness due to congenital transmission but also a significant opportunistic pathogen in AIDS patients and organ transplant recipients. In addition, CMV has been implicated as a pathogenic contributor in the development of atherosclerosis. Cancer has also been associated with herpesvirus infections. EBV is associated with Burkitt’s lymphoma, other B cell neoplasias and nasopharyngeal carcinoma. The most recent human herpesvirus discovered (HHV-8 or KSHV) is associated with Kaposi’s sarcoma in AIDS patients and other immunosuppressed persons in other groups. All of the herpesviruses persist for life and therefore pose significant problems in the treatment of immune-compromised individuals. Diseases caused by reactivation of most human herpesviruses are a significant cause of morbidity and mortality in various immune patient populations. Workshop sessions will take an interdisciplinary approach to the following topics: virus structure, mechanism of virus entry and cell-cell spread, membrane proteins, pathogenesis and latency, DNA replication, vaccination and the immune response, transcriptional control, regulation of gene expression, chemotherapeutic targets, and virus gene therapy.