International Herpesvirus Workshop

国际疱疹病毒研讨会

• 批准号: 9392092
• 负责人: JAY A NELSON
• 金额: $ 0.65万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-05 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9392092
• 关键词: Acquired Immunodeficiency Syndrome; Animal Disease Models; Animals; Antiviral Agents; Atherosclerosis; B-Lymphocytes; Belgium; Blindness; Books; Budgets; Burkitt Lymphoma; Cells; Chickenpox; Clinical Research; Communities; Congenital Abnormality; Cytomegalovirus; DNA biosynthesis; Data; Development; Disease; Educational workshop; Encephalitis; Ensure; Enzymatic Biochemistry; Eye; Fees; Fertilization; Fostering; Funding; Gene Expression Regulation; Gene Transduction Agent; Genital system; Genome; Grant; Herpes zoster disease; Herpesviridae; Herpesviridae Infections; Herpesvirus 1; Human; Human Herpesvirus 2; Human Herpesvirus 4; Human Herpesvirus 8; Immune; Immune Evasion; Immune response; Individual; Infection; Infectious Mononucleosis; International; Kaposi Sarcoma; Laboratories; Lesion; Life; Malignant Neoplasms; Medical; Membrane Proteins; Meningitis; Mental Retardation; Molecular Biology; Morbidity - disease rate; Nasopharynx Carcinoma; Neoplasms; Oral; Organ Transplantation; Participant; Pathogenesis; Pathogenicity; Patients; Persons; Postdoctoral Fellow; Prevention; Publishing; Request for Proposals; Research; Research Personnel; Resistance development; Rest; Scientist; Skin; Structure; Students; Talents; Training; Transcriptional Regulation; Transplant Recipients; Travel; Ulcer; United States National Institutes of Health; Universities; Vaccination; Viral; Viral Drug Resistance; Viral Vector; Virus; Work; base; cost; deafness; experience; gene therapy; graduate student; immunosuppressed; interdisciplinary approach; interest; meetings; mortality; pathogen; patient population; planetary Atmosphere; post-doctoral training; posters; symposium; transmission process; vaccine development; virus genetics

Project Summary This proposal requests funds to be used to support travel and registration fees for postdoctoral fellows and graduate students to attend the 42nd International Herpesvirus Workshop (IHW) in Ghent, Belgium, in 2017. The IHW is the major annual meeting for scientists studying all the herpesviruses and is very well established in its 42nd year. This meeting has been very successful, in part, because of the enthusiastic participation of the world’s leading herpesvirus researchers. The strength of the Workshop rests on the cross-fertilization that results from comparison of different herpesviruses, different approaches to key questions and on the support and participation of leading researchers in the field, most significantly including promising young investigators and students in training. Moreover, the forum is truly international, with broad-based world-wide attendance. The medical importance of this meeting is clearly indicated from the wide variety of diseases caused by the now-recognized eight human herpesviruses. These include skin and eye ulcerations (HSV-1), genital lesions (HSV-2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV). CMV is a major cause of birth defects including mental retardation, blindness and deafness due to congenital transmission but also a significant opportunistic pathogen in AIDS patients and organ transplant recipients. More recently, CMV has been implicated as a pathogenic contributor in the development of atherosclerosis. Cancer has also been associated with herpesvirus infections. EBV is associated with Burkitt’s lymphoma, other B cell neoplasias and nasopharyngeal carcinoma. The most recent human herpesvirus discovered (HHV-8 or KSHV) is associated with Kaposi’s sarcoma in AIDS patients and other immunosuppressed persons and in other groups. All of the herpesviruses persist for life and therefore pose significant problems in the treatment of immune-compromised individuals. Diseases caused by reactivation of most human herpesviruses are a significant cause of morbidity and mortality in various immune patient populations. Workshop sessions will take an interdisciplinary approach to the following topics: virus structure, mechanism of virus entry and cell-cell spread, membrane proteins, pathogenesis and latency, DNA replication, vaccination and the immune response, transcriptional control, regulation of gene expression, chemotherapeutic targets, and virus gene therapy.

项目摘要 该提案要求资金用于支持博士后研究员的旅行和注册费， 研究生将于2017年参加比利时根特的第42国际疱疹病毒研讨会（IHW）。 IHW是研究所有疱疹病毒的科学家的主要年度会议，并且已经建立得很好 在第42年。这次会议非常成功，部分原因是 世界领先的疱疹病毒研究人员。研讨会的强度取决于交叉利用 比较不同的疱疹病毒，关键问题的不同方法和支持的结果 并参与该领域的领先研究人员，最重要的包括有前途的年轻研究人员 和学生接受培训。此外，该论坛确实是国际性的，具有广泛的全球出勤率。 这次会议的医学重要性清楚地表明了由 现在已经认识到八个人类疱疹病毒。这些包括皮肤和眼睛溃疡（HSV-1），生殖器病变 （HSV-2），脑膜炎和脑炎（HSV-1和HSV-2），感染性单核细胞增多症（EBV），鸡肉痘和 带状疱疹（VZV）。 CMV是出生缺陷的主要原因，包括智力低下，失明和耳聋 由于先天性的传播，但同时也有大量的机会病原体病原体和器官 移植接受者。最近，CMV已作为发育的致病作用实施 动脉粥样硬化。癌症也与疱疹病毒感染有关。 EBV与 伯基特的淋巴瘤，其他B细胞肿瘤和鼻咽癌。最近的人 发现的疱疹病毒（HHV-8或KSHV）与Kaposi的肉瘤在艾滋病患者和其他 免疫抑制的人和其他群体。所有的疱疹病毒一生都持续存在，因此姿势 免疫受损个体的治疗中的重大问题。由 大多数人类疱疹病毒是各种免疫患者发病率和死亡率的重要原因 人群。研讨会会议将采用跨学科的方法来解决以下主题：病毒结构， 病毒进入和细胞细胞扩散的机制，膜蛋白，发病机理和潜伏期，DNA复制， 疫苗接种和免疫响应，转录控制，基因表达的调节，化学治疗 靶标和病毒基因治疗。