International Herpesvirus Workshop

国际疱疹病毒研讨会

• 批准号: 9392092
• 负责人: JAY A NELSON
• 金额: $ 0.65万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-05 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9392092
• 关键词: Acquired Immunodeficiency Syndrome; Animal Disease Models; Animals; Antiviral Agents; Atherosclerosis; B-Lymphocytes; Belgium; Blindness; Books; Budgets; Burkitt Lymphoma; Cells; Chickenpox; Clinical Research; Communities; Congenital Abnormality; Cytomegalovirus; DNA biosynthesis; Data; Development; Disease; Educational workshop; Encephalitis; Ensure; Enzymatic Biochemistry; Eye; Fees; Fertilization; Fostering; Funding; Gene Expression Regulation; Gene Transduction Agent; Genital system; Genome; Grant; Herpes zoster disease; Herpesviridae; Herpesviridae Infections; Herpesvirus 1; Human; Human Herpesvirus 2; Human Herpesvirus 4; Human Herpesvirus 8; Immune; Immune Evasion; Immune response; Individual; Infection; Infectious Mononucleosis; International; Kaposi Sarcoma; Laboratories; Lesion; Life; Malignant Neoplasms; Medical; Membrane Proteins; Meningitis; Mental Retardation; Molecular Biology; Morbidity - disease rate; Nasopharynx Carcinoma; Neoplasms; Oral; Organ Transplantation; Participant; Pathogenesis; Pathogenicity; Patients; Persons; Postdoctoral Fellow; Prevention; Publishing; Request for Proposals; Research; Research Personnel; Resistance development; Rest; Scientist; Skin; Structure; Students; Talents; Training; Transcriptional Regulation; Transplant Recipients; Travel; Ulcer; United States National Institutes of Health; Universities; Vaccination; Viral; Viral Drug Resistance; Viral Vector; Virus; Work; base; cost; deafness; experience; gene therapy; graduate student; immunosuppressed; interdisciplinary approach; interest; meetings; mortality; pathogen; patient population; planetary Atmosphere; post-doctoral training; posters; symposium; transmission process; vaccine development; virus genetics

Project Summary This proposal requests funds to be used to support travel and registration fees for postdoctoral fellows and graduate students to attend the 42nd International Herpesvirus Workshop (IHW) in Ghent, Belgium, in 2017. The IHW is the major annual meeting for scientists studying all the herpesviruses and is very well established in its 42nd year. This meeting has been very successful, in part, because of the enthusiastic participation of the world’s leading herpesvirus researchers. The strength of the Workshop rests on the cross-fertilization that results from comparison of different herpesviruses, different approaches to key questions and on the support and participation of leading researchers in the field, most significantly including promising young investigators and students in training. Moreover, the forum is truly international, with broad-based world-wide attendance. The medical importance of this meeting is clearly indicated from the wide variety of diseases caused by the now-recognized eight human herpesviruses. These include skin and eye ulcerations (HSV-1), genital lesions (HSV-2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV). CMV is a major cause of birth defects including mental retardation, blindness and deafness due to congenital transmission but also a significant opportunistic pathogen in AIDS patients and organ transplant recipients. More recently, CMV has been implicated as a pathogenic contributor in the development of atherosclerosis. Cancer has also been associated with herpesvirus infections. EBV is associated with Burkitt’s lymphoma, other B cell neoplasias and nasopharyngeal carcinoma. The most recent human herpesvirus discovered (HHV-8 or KSHV) is associated with Kaposi’s sarcoma in AIDS patients and other immunosuppressed persons and in other groups. All of the herpesviruses persist for life and therefore pose significant problems in the treatment of immune-compromised individuals. Diseases caused by reactivation of most human herpesviruses are a significant cause of morbidity and mortality in various immune patient populations. Workshop sessions will take an interdisciplinary approach to the following topics: virus structure, mechanism of virus entry and cell-cell spread, membrane proteins, pathogenesis and latency, DNA replication, vaccination and the immune response, transcriptional control, regulation of gene expression, chemotherapeutic targets, and virus gene therapy.

项目总结