International Herpesvirus Workshop

项目摘要 这项提案要求资金用于支持博士后研究员的旅费和注册费，并 研究生参加2017年在比利时根特举行的第42届国际疱疹病毒研讨会(IHW)。 IHW是科学家研究所有疱疹病毒的主要年度会议，历史悠久 在它的第42个年头。这次会议非常成功，部分原因是 世界领先的疱疹病毒研究人员。研讨会的优势在于相互受精， 比较不同的疱疹病毒、解决关键问题的不同方法和对支持的结果 以及该领域领先研究人员的参与，最重要的是包括有前途的年轻研究人员 以及正在接受培训的学生。此外，该论坛具有真正的国际性，出席者基础广泛，遍及世界各地。 这次会议的医学重要性从由 现在公认的八种人类疱疹病毒。这些疾病包括皮肤和眼睛溃疡(HSV-1)、生殖器损伤 (HSV-2)、脑膜炎和脑炎(HSV-1和HSV-2)、传染性单核细胞增多症(EBV)、水痘和 带状疱疹(VZV)。巨细胞病毒是导致出生缺陷的主要原因，包括智力低下、失明和耳聋。 由于先天传播，也是艾滋病患者重要的机会性病原体和器官 移植受者。最近，巨细胞病毒被认为是致病因素之一。 动脉粥样硬化。癌症也与疱疹病毒感染有关。EB病毒与 Burkitt淋巴瘤、其他B细胞肿瘤和鼻咽癌。最新的人类 在艾滋病患者和其他患者中发现的疱疹病毒(HHV-8或KSHV)与卡波西肉瘤有关 免疫抑制者和其他组。所有的疱疹病毒都会持续一生，因此会 免疫受损个体的治疗中存在的重大问题。因重新激活而引起的疾病 大多数人类疱疹病毒是各种免疫患者发病和死亡的重要原因 人口。研讨会将对以下主题采取跨学科的方法：病毒结构， 病毒进入和细胞间传播的机制，膜蛋白，发病机制和潜伏期，DNA复制， 疫苗接种与免疫反应、转录调控、基因表达调控、化疗 靶点和病毒基因疗法。

Project Summary This proposal requests funds to be used to support travel and registration fees for postdoctoral fellows and graduate students to attend the 42nd International Herpesvirus Workshop (IHW) in Ghent, Belgium, in 2017. The IHW is the major annual meeting for scientists studying all the herpesviruses and is very well established in its 42nd year. This meeting has been very successful, in part, because of the enthusiastic participation of the world’s leading herpesvirus researchers. The strength of the Workshop rests on the cross-fertilization that results from comparison of different herpesviruses, different approaches to key questions and on the support and participation of leading researchers in the field, most significantly including promising young investigators and students in training. Moreover, the forum is truly international, with broad-based world-wide attendance. The medical importance of this meeting is clearly indicated from the wide variety of diseases caused by the now-recognized eight human herpesviruses. These include skin and eye ulcerations (HSV-1), genital lesions (HSV-2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV). CMV is a major cause of birth defects including mental retardation, blindness and deafness due to congenital transmission but also a significant opportunistic pathogen in AIDS patients and organ transplant recipients. More recently, CMV has been implicated as a pathogenic contributor in the development of atherosclerosis. Cancer has also been associated with herpesvirus infections. EBV is associated with Burkitt’s lymphoma, other B cell neoplasias and nasopharyngeal carcinoma. The most recent human herpesvirus discovered (HHV-8 or KSHV) is associated with Kaposi’s sarcoma in AIDS patients and other immunosuppressed persons and in other groups. All of the herpesviruses persist for life and therefore pose significant problems in the treatment of immune-compromised individuals. Diseases caused by reactivation of most human herpesviruses are a significant cause of morbidity and mortality in various immune patient populations. Workshop sessions will take an interdisciplinary approach to the following topics: virus structure, mechanism of virus entry and cell-cell spread, membrane proteins, pathogenesis and latency, DNA replication, vaccination and the immune response, transcriptional control, regulation of gene expression, chemotherapeutic targets, and virus gene therapy.