Training in Early Detection and Prevention in Psychiatric Disorders

精神疾病早期检测和预防培训

• 批准号: 7869253
• 负责人: TYRONE D CANNON
• 金额: $ 21.53万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7869253
• 关键词: Early Diagnosis; Mental disorders; Prevention; Training

DESCRIPTION (provided by applicant): We propose a novel program for post-doctoral training in early detection and prevention of psychotic disorders, mood disorders, and anxiety disorders. Because these disorders strike relatively early in life and tend to be chronic and debilitating, individuals with these conditions utilize a disproportionate share of public funds for medical services and disability. Existing treatments are only partially effective in reducing symptom severity, generally requiring on-going maintenance therapy to do so (with accumulating side effect burden), and do not ameliorate the deficits in occupational and social functioning associated with these syndromes or the vulnerability to future episodes. In addition, for some of these conditions, the earlier treatment is initiated after the onset of illness, the better the long-term outcome, suggesting that progressive aspects of the underlying disease processes make these illnesses increasingly less responsive to interventions. This program will integrate didactic coursework, seminars, and supervised research training in early detection and prevention of psychiatric disorders. We integrate mechanisms to evaluate trainees and the program in relation to four objectives. First, progress toward effective prevention programs for these disorders will be more rapid if the next generation of researchers is armed with the tools needed both to ascertain risk markers and mechanisms and to develop and test preventive interventions. Second, given that these forms of psychopathology are complexly determined phenomena, involving biological and psychosocial processes, the next generation of researchers must be able to integrate effectively across these different levels of analysis in their approach to risk detection and preventive intervention. Third, our focus on transitional age populations will help to overcome the traditional boundaries between research in adolescent and adult forms of psychopathology, facilitating the integration of a developmental perspective. Finally, exposure of trainees to early detection and prevention approaches to multiple domains of psychopathology will provide useful points of comparison and contrast and will stimulate cross-fertilization between areas.

描述（由申请人提供）：我们提出了一个新颖的计划，用于早期发现和预防精神病，情绪障碍和焦虑症的新颖计划。由于这些疾病在生活中相对较早，并且往往是长期和使人衰弱的，因此患有这些疾病的人会利用不成比例的公共资金来用于医疗服务和残疾。现有治疗仅在减轻症状严重程度方面有效，通常需要进行持续的维持治疗（累积的副作用负担），并且不会改善与这些综合症相关的职业和社会功能的缺陷或对未来发作的脆弱性。此外，对于其中一些疾病，疾病发作后会开始较早的治疗方法，长期结局越好，这表明基本疾病过程的渐进方面使这些疾病对干预措施的反应越来越小。该计划将在早期发现和预防精神疾病的早期检测和预防研究中整合教学课程，研讨会和监督研究培训。我们集成了与四个目标有关的学员评估学员和计划的机制。首先，如果下一代研究人员拥有确定风险标志物和机制并制定和测试预防性干预措施所需的工具，则朝着这些疾病有效预防计划的进展将更加迅速。其次，鉴于这些形式的心理病理学是复杂的现象，涉及生物学和社会心理过程，因此下一代研究人员必须能够在其风险检测和预防性干预的方法中有效地整合在这些不同级别的分析中。第三，我们对过渡年龄人口的关注将有助于克服青少年和成人形式的心理病理学研究之间的传统界限，从而促进发展观点的整合。最后，受训者接触早期检测和预防方法，对多个心理病理学领域将提供比较和对比的有用点，并刺激区域之间的交叉施用。