1/8-Predictors and Mechanisms of Conversion to Psychosis
1/8-转变为精神病的预测因素和机制
基本信息
- 批准号:7871117
- 负责人:
- 金额:$ 20.88万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-07-01 至 2011-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdolescentAffectAffectiveAgeAge of OnsetAlgorithmsAntipsychotic AgentsAttentionBiologicalBiological MarkersBrainCandidate Disease GeneChronicClinicalDNADSM-IVDataData SetDeteriorationDevelopmentDiagnosticDiseaseEP300 geneEarly DiagnosisEconomicsElectrophysiology (science)ElementsEnrollmentEpidemiologyEtiologyFamilyFunctional disorderFundingFutureGeneticGenetic Predisposition to DiseaseGenomicsHeterogeneityHormonalHormonesHydrocortisoneImpairmentIncidenceIndividualInterventionKnowledgeLifeLongitudinal StudiesMeasuresMedialMemoryMeta-AnalysisMethodologyNational Institute of Mental HealthNeurobiologyNeurocognitionNeurocognitiveNorth AmericaOutcomeParanoiaPathway interactionsPatientsPerformancePersonsPhasePopulationPreventionPrevention strategyPreventive InterventionProblem SolvingProcessProspective StudiesProtocols documentationPsychosocial FactorPsychotic DisordersRNARecruitment ActivityResearchRiskSample SizeSamplingSchizophreniaSeriesSiteSocietiesStressStructureSubgroupSyndromeTemporal LobeTestingTimeWorkbasedeviantendophenotypeexecutive functionfollow-upgray matterhelp-seeking behaviorhigh riskimprovedinstrumentinterestmeetingsneuroimagingneuromechanismneurophysiologypreventprogramsprogression markerprospectivepsychosocialrepositorysocial
项目摘要
Schizophrenia and other forms of psychosis affect approximately 3% of the population with a disorder that is
usually chronic and disabling. The peak age of onset is between ages 18-30, occurring just as life's most
productive years are beginning. Although genetic liability and abnormal brain development are known
contributing factors, the etiology and pathophysiology of schizophrenia and related syndromes is largely
unknown. To date, prospective observation of onset, i.e., the transition from vulnerability to disorder, has not
been possible because most persons at true risk cannot be identified premorbidly. This has hampered efforts
at prevention. However, recent progress in risk ascertainment methodology has enabled reliable identification
of help-seeking persons with pre-psychotic or "prodromal" clinical syndromes who develop psychosis within 1-2
years at rates between 20%-50%. Thus, clinical high-risk populations are now available for tracking
prospectively the development and emergence of psychosis. However, because of the low incidence of
schizophrenia and the heterogeneity of outcomes in clinical high-risk cases, single site studies cannot
efficiently exploit the risk criteria in identifying predictors and mechanisms of psychosis. The NAPLS
consortium was created to solve this problem. Eight NIMH-funded sites in North America studying prodromal
patients using a common prodromal assessment instrument pooled data to create the largest sample of such
persons worldwide (N=291), 35% of whom converted to psychosis after 2¿ years. An algorithm of baseline
data was generated predicting psychosis with about 80% positive predictive power and 40% sensitivity. In this
revised proposal, we describe a collaborative prospective study for which we will recruit 800 cases and 400
appropriate controls over 5 years using common, standardized clinical and neurobiological measures. The aim
is to collect a sample with sufficient size and power to rigorously test elements critical to the liability for and
development of psychosis in the biomarker domains of brain structure, electrophysiology, stress hormones,
and genomics, and in the clinical domains of prodromal presentation and epidemiology. The revised proposal
addresses reviewers' concerns, including the integration of the research plan and measures into a unifying
framework. The findings will enhance our ability to identify persons at high risk for imminent psychosis, by
refining predictors of conversion, and expanding our understanding of the underlying neural mechanisms. Such
knowledge is critical for future efforts at early detection, intervention and prevention of psychotic disorders. Preventing schizophrenia and other psychoses could relieve an enormous burden of personal and family
suffering and economic losses to society. This 8-site project aims to increase our ability to identify high-risk
individuals prior to onset and to pinpoint neurobiological changes that underlie the emergence of a psychotic
disorder. These efforts are critical to the development of effective preventative intervention strategies for
psychotic disorders.
精神分裂症和其他形式的精神病影响了大约3%的患有精神障碍的人群
项目成果
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{{ truncateString('TYRONE D CANNON', 18)}}的其他基金
NEURAL PHENOTYPES FOR SCHIZOPHRENIA AND BIPOLAR DISORDER
精神分裂症和双向情感障碍的神经表型
- 批准号:
8363431 - 财政年份:2011
- 资助金额:
$ 20.88万 - 项目类别:
NAPLS: NORTH AMERICAN PRODROMAL LONGITUDINAL STUDY
NAPLS:北美前驱纵向研究
- 批准号:
8363493 - 财政年份:2011
- 资助金额:
$ 20.88万 - 项目类别:
NEURAL PHENOTYPES FOR SCHIZOPHRENIA AND BIPOLAR DISORDER
精神分裂症和双向情感障碍的神经表型
- 批准号:
8171041 - 财政年份:2010
- 资助金额:
$ 20.88万 - 项目类别:
NEURAL PHENOTYPES FOR SCHIZOPHRENIA AND BIPOLAR DISORDER
精神分裂症和双向情感障碍的神经表型
- 批准号:
7955647 - 财政年份:2009
- 资助金额:
$ 20.88万 - 项目类别:
Prevention Trial of Family Focused Treatment in Youth at Risk for Psychosis
对有精神病风险的青少年进行以家庭为中心的治疗的预防试验
- 批准号:
7941766 - 财政年份:2009
- 资助金额:
$ 20.88万 - 项目类别:
EARLY IDENTIFICATION AND CHARACTERIZATION OF THE PRODROMAL PHASE OF THOUGHT DISO
思想 DISO 前驱阶段的早期识别和表征
- 批准号:
8167140 - 财政年份:2009
- 资助金额:
$ 20.88万 - 项目类别:
Training in Early Detection and Prevention in Psychiatric Disorders
精神疾病早期检测和预防培训
- 批准号:
8076831 - 财政年份:2009
- 资助金额:
$ 20.88万 - 项目类别:
Prevention Trial of Family Focused Treatment in Youth at Risk for Psychosis
对有精神病风险的青少年进行以家庭为中心的治疗的预防试验
- 批准号:
7821547 - 财政年份:2009
- 资助金额:
$ 20.88万 - 项目类别:
Training in Early Detection and Prevention in Psychiatric Disorders
精神疾病早期检测和预防培训
- 批准号:
7869253 - 财政年份:2009
- 资助金额:
$ 20.88万 - 项目类别:
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