Defining the cellular origin of chronic lymphocytic leukaemia

定义慢性淋巴细胞白血病的细胞起源

• 批准号: G0601099/1
• 负责人: Alison Michie
• 金额: $ 46.36万
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0601099%2F1
• 关键词: Defining; cellular; origin; chronic; lymphocytic

Leukaemia is a cancer that results from a disruption in the normal development of cells within the blood. This disruption can occur when regulatory elements responsible for controlling white blood cell development malfunction. We recently discovered that a disturbance in the function of a ubiquitously expressed element protein kinase C during white blood cell development, initiates a specific type of leukaemia, chronic lymphocytic leukaemia (CLL). CLL is the most common adult blood cancer in the Western world, for which there is currently no cure. While many research groups are engaged in investigating the mechanisms that can induce CLL cell death in patients as a mechanism to remove the leukaemic cells, little is known about the origin of CLL cells. Until now it has been almost impossible to address this question, as the factors responsible for this initiating this leukaemia have remained elusive. However, our novel mouse model provides us with a unique opportunity to gain fundamental knowledge about the cellular origin of CLL, and may assist in the generation of novel treatments to cure CLL. Within our university-based research laboratory, we will perform established cellular and molecular techniques to identify which cell is responsible initiating CLL. In parallel with these experiments, we will characterise the CLL-initiating cells in CLL-patient cell samples. In this way, we will uncover important information regarding the cell of origin for CLL.

白血病是一种由于血液中细胞的正常发育中断而导致的癌症。当负责控制白细胞发育故障的调节元件时，这种干扰就会发生。我们最近发现，在白细胞发育过程中，一种普遍表达的蛋白激酶C的功能紊乱，会引发一种特殊类型的白血病，即慢性淋巴细胞白血病(CLL)。慢性淋巴细胞性白血病是西方世界最常见的成人血癌，目前还没有治愈方法。虽然许多研究小组都致力于研究诱导患者CLL细胞死亡的机制，以此作为清除白血病细胞的机制，但对CLL细胞的起源知之甚少。到目前为止，几乎不可能解决这个问题，因为引发这种白血病的因素仍然难以捉摸。然而，我们的新的小鼠模型为我们提供了一个独特的机会来获得关于CLL细胞起源的基础知识，并可能有助于产生治疗CLL的新方法。在我们大学的研究实验室内，我们将执行既定的细胞和分子技术，以确定哪个细胞负责启动CLL。在这些实验的同时，我们将描述CLL患者细胞样本中启动CLL的细胞的特征。通过这种方式，我们将发现有关CLL起源细胞的重要信息。