Mechanistic Core

机械核心

基本信息

  • 批准号:
    8022463
  • 负责人:
  • 金额:
    $ 47.84万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-07-01 至 2015-06-30
  • 项目状态:
    已结题

项目摘要

The broad goals of the Mechanistic Core are the following: 1) to continue mechanistic studies from the prior granting period aimed at defining the mechanisms underlying the development of food allergy and "natural" or immunotherapeutically-induced tolerance, 2) to provide a platform for every project within this new proposal to achieve these goals and 3) to utilize the information gathered during the initial granting period to establish new hypotheses and provide new avenues for investigation. During the initial granting period we established uniform reproducible technology across 5 sites allowing for the study of sensitization and T-cell activation, and assessment of the development of tolerance. There were several findings that caused us to question some of the previous dogma including the fact that a large cohort of milk and egg allergic children were already sensitized to peanut at an early age, that the GATA-3 transcription factor may play less of a role in allergic sensitization in humans than previously thought and that there was a high likelihood of a non- T cell origin for IL-4 (and consequent IgE) in these patients. The current proposal seeks to continue the current studies focused on the role of T cells vs. APCs in allergic sensitization and tolerance, as well as expand studies on the role of basophils in this process. In addition, we now plan to specifically explore the expression and regulation of GATA-3 in T and non-T cells, initiate studies attempting to correlate the expression of food allergy as either atopic, i.e. atopic dermatitis, asthma or allergic rhinitis, vs eosinophilic esophagitis using the immunologic parameters previously described, and finally to use a microarray approach to define novel pathways and markers of atopic disease, disease resolution and tolerance and the distinct expression of disease phenotypes (AD vs EE). These ongoing and new studies should enhance our understanding of the pathogenesis of atopic disease based upon human study.
机械核心的广泛目标如下:1)继续从先前授予期开始的机制研究,旨在确定食物过敏和“天然”或免疫治疗诱导的耐受性发展的潜在机制,2)为新提案中的每个项目提供一个平台,以实现这些目标; 3)利用在最初授予期间收集的信息,建立新的假设,并提供新的调查途径。在最初的授予期间,我们在5个地点建立了统一的可重复技术,以便研究致敏性和T细胞活化,并评估耐受性的发展。有几个发现使我们质疑以前的一些教条,包括一个事实,即大量牛奶和鸡蛋过敏的儿童在很小的时候就已经对花生过敏,加塔-3转录因子在人类过敏性致敏中的作用可能比以前认为的要小,并且IL-4很可能是非T细胞来源的(以及随后的IgE)。目前的建议旨在继续 目前的研究集中在T细胞相对于APC在过敏性致敏和耐受中的作用,以及对嗜碱性粒细胞在该过程中的作用的扩展研究。此外,我们现在计划专门研究加塔-3在T细胞和非T细胞中的表达和调节,开始尝试使用先前描述的免疫学参数将食物过敏的表达与特应性(即特应性皮炎、哮喘或过敏性鼻炎)和嗜酸性食管炎相关联的研究,并最终使用微阵列 方法来定义特应性疾病的新途径和标志物,疾病的解决和耐受性以及疾病表型(AD与EE)的不同表达。这些正在进行的和新的研究应加强我们对特应性疾病的发病机制的理解,基于人类的研究。

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Lloyd F Mayer其他文献

CORRELATION OF IMMUNE RESPONSES WITH HIV PLASMA VIREMIA. † 1074
  • DOI:
    10.1203/00006450-199604001-01096
  • 发表时间:
    1996-04-01
  • 期刊:
  • 影响因子:
    3.100
  • 作者:
    Vicki B Peters;Mary E Klotman;Lloyd F Mayer;Laura Pustilnik;Erica Sapira;Kirk E Sperber
  • 通讯作者:
    Kirk E Sperber

Lloyd F Mayer的其他文献

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{{ truncateString('Lloyd F Mayer', 18)}}的其他基金

Innate/Adaptive Immune Interactions in Gut Inflammation
肠道炎症中的先天/适应性免疫相互作用
  • 批准号:
    7923501
  • 财政年份:
    2009
  • 资助金额:
    $ 47.84万
  • 项目类别:
Tolerance vs. Allergenicity; Factors Dictating Differing Responses
耐受性与过敏性;
  • 批准号:
    7976575
  • 财政年份:
    2009
  • 资助金额:
    $ 47.84万
  • 项目类别:
Generation and characterization of intestinal CD8+ regulatory T cell lines
肠道 CD8 调节性 T 细胞系的产生和表征
  • 批准号:
    7821735
  • 财政年份:
    2009
  • 资助金额:
    $ 47.84万
  • 项目类别:
Generation and characterization of intestinal CD8+ regulatory T cell lines
肠道 CD8 调节性 T 细胞系的产生和表征
  • 批准号:
    7943126
  • 财政年份:
    2009
  • 资助金额:
    $ 47.84万
  • 项目类别:
Tolerance vs. Allergenicity; Factors Dictating Differing Responses
耐受性与过敏性;
  • 批准号:
    7476107
  • 财政年份:
    2008
  • 资助金额:
    $ 47.84万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    7499463
  • 财政年份:
    2007
  • 资助金额:
    $ 47.84万
  • 项目类别:
BACTERIAL;EPITHELIAL; T-CELL INTERACTIONS IN GUT MUCOSA
细菌;上皮;
  • 批准号:
    7484980
  • 财政年份:
    2007
  • 资助金额:
    $ 47.84万
  • 项目类别:
Innate/Adaptive Immune Interactions in Gut Inflammation
肠道炎症中的先天/适应性免疫相互作用
  • 批准号:
    7921636
  • 财政年份:
    2006
  • 资助金额:
    $ 47.84万
  • 项目类别:
Innate/Adaptive Immune Interactions in Gut Inflammation
肠道炎症中的先天/适应性免疫相互作用
  • 批准号:
    8214199
  • 财政年份:
    2006
  • 资助金额:
    $ 47.84万
  • 项目类别:
Novel Mucosal Regulatory DC4+ T Cells: Interface Between Th17 and Treg
新型粘膜调节 DC4 T 细胞:Th17 和 Treg 之间的界面
  • 批准号:
    8730608
  • 财政年份:
    2006
  • 资助金额:
    $ 47.84万
  • 项目类别:

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