Appalachian Tri-State Node

阿巴拉契亚三州节点

• 批准号: 7982809
• 负责人: DENNIS C DALEY
• 金额: $ 104.53万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7982809
• 关键词: Address; Adoption; Behavioral; Clinic; Clinical; Clinical Trials; Clinical Trials Network; Communities; Comorbidity; Conduct Clinical Trials; Country; Drug abuse; Education; Effectiveness; Effectiveness of Interventions; Ensure; Evidence based treatment; Family; Funding; Future; Goals; HIV; Health Personnel; High Prevalence; Housing; Institutes; Intervention; Location; Manuals; Medical; Medicine; Mental Health; Meridians; Mission; Multi-Institutional Clinical Trial; National Institute of Drug Abuse; Office of Administrative Management; Patients; Pharmaceutical Preparations; Physicians; Population; Primary Health Care; Principal Investigator; Progress Reports; Protocols documentation; Provider; Psychiatric therapeutic procedure; Randomized; Research; Research Infrastructure; Research Training; Science; Screening procedure; Services; Site; Substance Use Disorder; System; Training; Training Programs; Treatment outcome; Work; Writing; addiction; community based treatment; cost; cost effectiveness; dissemination research; improved; lectures; meetings; patient population; protocol development; public health relevance; response; symposium; working group

DESCRIPTION (provided by applicant): This is a competing renewal application by the Appalachian Tri-State (ATS) Node of NIDA's Clinical Trials Network (CTN) in response to RFA-DA-10-009. During the previous funding period, the ATS Node made substantial contributions to CTN research, dissemination and administrative activities. We collaborated effectively with NIDA, other Nodes and community treatment providers (CTPs) in advancing the mission of the CTN by: 1) participating in four clinical trials and preparing for a fifth; 2) contributing to new protocols under review; 3) writing a treatment manual for a trial; 4) developing and delivering clinical training protocols and fidelity scales for experimental interventions; 5) disseminating information about NIDA Evidenced-Based Treatments (EBTs) through lectures, training programs, conferences, writings for professionals and writings for patients with drug problems; and 6) participating in CTN committees, work groups and national and regional dissemination conference planning committees. Four new CTN trials were implemented during the past 4 years and ATS was one of three CTN Nodes that participated in all four, having excellent subject recruitment for three of four CTN studies by exceeding our original recruitment goals by randomizing 255 subjects in these trials. In response to the changing research needs of NIDA to conduct clinical trials in non-addiction treatment settings, the ATS node expanded our CTPs to include medical and psychiatric systems and an HIV primary care clinic. To demonstrate our ability to contribute conceptually to future CTN projects, we propose a research agenda that focuses on studies of substance use disorders (SUDs) that co-occur with psychiatric and/or medical conditions. Studies of co-occurring medical and mental health conditions are needed because of the high prevalence of SUDs among those who have other illnesses and the lack of studies for many specialized clinical populations, especially patients in medical settings. Potential CTN studies could focus on screening, identifying and engaging patients with SUDs in these non-addiction settings as well as examining dissemination and cost-effectiveness of the interventions. PUBLIC HEALTH RELEVANCE: The funded application will improve the quality of drug abuse treatment throughout the country by conducting studies of behavioral, pharmacological, and integrated treatment interventions in rigorous, multi-site clinical trials to determine effectiveness across a broad range of treatment settings and diversified patient populations; and to ensuring the transfer of research results to physicians, clinicians, providers, and patients.

描述（由申请人提供）：这是NIDA临床试验网络（CTN）的阿巴拉契亚三州（ATS）节点响应RFA-DA-10-009的竞争性更新申请。在上一个供资期间，安非他明类兴奋剂联络点为气候技术网络的研究、传播和行政活动作出了重大贡献。我们与NIDA、其他节点和社区治疗提供者（CTPs）有效合作，通过以下方式推进CTN的使命：1）参与四项临床试验，并为第五项临床试验做准备; 2）为正在审查的新方案做出贡献; 3）为试验编写治疗手册; 4）开发和提供临床培训方案和实验干预的保真度量表; 5）通过讲座，培训计划，会议，专业人士的文章和药物问题患者的文章传播有关NIDA循证治疗（EBT）的信息;和6）参加CTN委员会，工作组和国家和区域传播会议规划委员会。在过去4年中实施了4项新的CTN试验，ATS是参与所有4项试验的3个CTN节点之一，通过在这些试验中随机分配255例受试者，超过了我们最初的招募目标，在4项CTN研究中的3项中招募了优秀的受试者。 为了应对NIDA不断变化的研究需求，在非成瘾治疗环境中进行临床试验，ATS节点扩大了我们的CTP，包括医疗和精神病系统和艾滋病毒初级保健诊所。为了证明我们有能力在概念上为未来的CTN项目做出贡献，我们提出了一个研究议程，重点是研究与精神和/或医疗条件共同发生的物质使用障碍（SUD）。由于SUD在患有其他疾病的人群中的高患病率以及缺乏对许多专业临床人群（特别是医疗环境中的患者）的研究，因此需要对同时发生的医疗和精神健康状况进行研究。潜在的CTN研究可以集中在筛查，识别和参与这些非成瘾环境中的SUD患者，以及检查干预措施的传播和成本效益。 公共卫生相关性：资助的申请将通过在严格的多地点临床试验中进行行为，药理学和综合治疗干预措施的研究来提高全国药物滥用治疗的质量，以确定广泛的治疗环境和多样化患者人群的有效性;并确保研究结果转移给医生，临床医生，提供者和患者。